奥硝唑合剂联合单次根管治疗对牙髓病患者的疗效与牙周微生态影响分析  

Analysis of the Efficacy of Ornidazole Combined with Single-Visit Root Canal Treatment on Patients with Pulp Disease and Its Impact on Periodontal Microecology

作　　者：高崇 王智源 杨永飞 刘洋 GAO Chong;WANG Zhiyuan;YANG Yongfei;LIU Yang(Department of Stomatology,Zhoukou Traditional Chinese Medicine Hospital,Zhoukou Henan 466099,China)

机构地区：[1]周口市中医院口腔科,河南周口466099

出　　处：《临床研究》2025年第1期58-61,共4页Clinical Research

摘　　要：目的探究奥硝唑合剂与单次根管手术相结合对牙髓疾病患者治疗效果及牙周微生物平衡的潜在作用。方法选取2022年1月至2023年12月周口市中医院口腔科接收的64名牙体牙髓疾病患者作为实验样本。通过随机数字表法,将患者平均分为对照组和观察组,每组各32人。对照组接受单次根管治疗,而观察组在对照组治疗基础上额外使用奥硝唑合剂。评估两组患者的临床治疗效果、咬合力量、咀嚼功能、牙龈沟液中的炎症指标[白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]、牙周微生物指标[牙龈指数(GI)、龈沟出血指数(SBI)]及并发症的发生情况(感染、牙龈炎症、咬合不适和疼痛)。结果观察组治疗有效率(100.00%)高于对照组(78.12%),差异有统计学意义(P<0.05)。治疗前,两组咬合力与咀嚼效能比较,差异无统计学意义(P>0.05);治疗后,两组咬合力与咀嚼效能均有显著增加,且观察组咬合力与咀嚼效能均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-6和TNF-α水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6和TNF-α水平均降低,且观察组IL-6和TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组GI、SBI水平比较,差异无统计学意义(P>0.05);治疗后,两组GI、SBI水平均降低,且观察组GI、SBI水平低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率(6.25%)明显低于对照组(28.12%),差异有统计学意义(P<0.05)。结论采用奥硝唑合剂配合单次根管填充治疗牙齿和牙髓疾病效果显著,可增强患者的咬合力和咀嚼功能,改善牙周健康状况及炎症反应,减少并发症发生情况。Objective To explore the therapeutic effect of ornidazole combined with single-visit root canal treatment on patients with pulp diseases and its potential role in maintaining periodontal microbial balance.Methods A total of 64 patients with dental pulp diseases who were treated at the Department of Stomatology of Zhoukou Traditional Chinese Medicine Hospital from January 2022 to December 2023 were selected as study subjects.Using a random number table method,patients were equally divided into a control group and an observation group,with 32 patients in each group.The control group received single-visit root canal treatment,while the observation group additionally received ornidazole combined with the control treatment.The clinical treatment effects,occlusal force,masticatory function,inflammatory indicators in gingival crevicular fluid[interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)],periodontal microbial indicators[gingival index(GI)and sulcus bleeding index(SBI)],and the incidence of complications(infection,gingival inflammation,occlusal discomfort,and pain)were assessed for both groups.Results The effective treatment rate in the observation group(100.00%)was significantly higher than that in the control group(78.12%),with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in occlusal force and masticatory efficiency between the two groups(P>0.05);however,after treatment,both groups showed a significant increase in occlusal force and masticatory efficiency,with the observation group showing higher values than the control group(P<0.05).Before treatment,there were no statistically significant differences in levels of IL-6 and TNF-αbetween the two groups(P>0.05);after treatment,levels of IL-6 and TNF-αdecreased in both groups,and the observation group had significantly lower levels than the control group(P<0.05).Before treatment,no significant difference was noted in GI and SBI levels between the groups(P>0.05);after treatment,GI and SBI l

关 键 词：奥硝唑 根管治疗 牙髓病 咬合力 炎性指标 

分 类 号：R781.05[医药卫生—口腔医学]