中风回春片对急性脑梗死恢复期患者的影响  

The Effects of Zhongfeng Huichun tablets on Patients in the Recovery Phase of Acute Cerebral Infarction

作　　者：郭东玲[1] 金鑫 董艳丽[1] GUO Dongling;JIN Xin;DONG Yanli(Department of General Medicine,Zhengzhou Second People's Hospital,Zhengzhou Henan 450000,China;Department of Traditional Chinese Medicine,Zhengzhou Second People's Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市第二人民医院全科医学科,河南郑州450000 [2]郑州市第二人民医院中医科,河南郑州450000

出　　处：《临床研究》2025年第1期95-99,共5页Clinical Research

摘　　要：目的将中风回春片应用于急性脑梗死(ACI)恢复期患者治疗,观察其临床疗效、神经功能及安全性。方法选取2019年9月至2023年6月郑州市第二人民医院收治的86例ACI恢复期患者,采用随机数字表法将其分为对照组(n=43,常规西药治疗)和试验组(n=43,采用中风回春片联合常规西药治疗)。比较两组患者临床疗效、中医症状积分、血清炎症因子[白细胞介素-6(IL-6)、转化生长因子-β(TGF-β)、超敏C反应蛋白(hs-CRP)]、神经营养指标[神经生长因子(NGF)、脑源性神经营养因子(BDNF)、胰岛素样生长因子1(IGF-1)]、神经损伤指标[心型脂肪酸结合蛋白(H-FABP)、S-100B蛋白(S100B)、神经元特异性烯醇化酶(NSE)]及不良反应发生率。结果试验组治疗有效率(93.02%)高于对照组(72.09%)差异具有统计学意义(P<0.05)。治疗前,两组中医症状积分比较,差异无统计学意义(P>0.05);治疗后,两组中医症状积分均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组各项炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,两组患者IL-6、hs-CRP水平较治疗前均降低,且试验组低于对照组,TGF-β水平较治疗前升高,且试验组高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组神经营养因子水平比较,差异无统计学意义(P>0.05);治疗后,两组NGF、BDNF、IGF-1水平较治疗前均升高,且试验组高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组神经损伤指标比较,差异无统计学意义(P>0.05);治疗后,两组患者H-FABP、S100B、NSE水平较治疗前均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论中风回春片联合常规西药可有效提高ACI恢复期患者的临床疗效,改善患者的中医症状,促进患者神经功能恢复,且安全性佳。Objective To observe the clinical efficacy,neurological function,and safety of Zhongfeng Huichun tablets in patients during the recovery phase of acute cerebral infarction(ACI).Methods A total of 86 ACI patients in the recovery phase who were treated at Zhengzhou Second People’s Hospital from September 2019 to June 2023 were selected and randomly divided into a control group(n=43,receiving conventional Western medication)and an experimental group(n=43,receiving Zhongfeng Huichun tablets in combination with conventional Western medication).The clinical efficacy,Traditional Chinese Medicine symptom scores,serum inflammatory factors[interleukin-6(IL-6),transforming growth factor-beta(TGF-β),high-sensitivity C-reactive protein(hs-CRP)],neurotrophic factors[nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),insulin-like growth factor-1(IGF-1)],neuroinjury markers[heart-type fatty acid binding protein(H-FABP),S100B protein(S100B),neuron-specific enolase(NSE)],and the incidence of adverse reactions were compared between the two groups.Results The treatment effective rate was significantly higher in the experimental group(93.02%)than that in the control group(72.09%),with statistically significant differences(P<0.05).There were no statistically significant differences in Traditional Chinese Medicine symptom scores between the two groups before treatment(P>0.05);however,both groups showed a decrease in symptom scores post-treatment,with the experimental group reporting lower scores than the control group,statistically significant differences were observed(P<0.05).Before treatment,there were no statistically significant differences in inflammatory factor levels(P>0.05);after treatment,IL-6 and hs-CRP levels decreased in both groups,with the experimental group showing lower levels compared to the control group.Conversely,TGF-βlevels increased in both groups,with the experimental group having higher levels than the control group,with statistically significant differences(P<0.05).Before treatment,there were

关 键 词：急性脑梗死恢复期 中风回春片 神经营养 神经损伤 

分 类 号：R743[医药卫生—神经病学与精神病学]