巨噬细胞极化在癌症骨转移中的研究进展  

Research progress on macrophage polarization in cancer bone metastasis

作　　者：李享 文振宇 黄启平 杨溢 吴洪瀚 瓦庆德 LI Xiang;WEN Zhenyu;HUANG Qiping;YANG Yi;WU Honghan;WA Qingde(Department of Orthopedics,Second Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学第二附属医院骨科,贵州遵义563000

出　　处：《重庆医学》2024年第24期3793-3799,共7页Chongqing Medical Journal

基　　金：国家自然科学基金项目(82160577)。

摘　　要：骨转移是许多晚期癌症的常见并发症,尤其是前列腺癌(85%)、乳腺癌(70%)及肺癌(40%)等,严重影响患者生活质量并增加其死亡风险。巨噬细胞是人体内重要的免疫细胞,在肿瘤微环境(TME)中起着关键作用,其作用包括吞噬或清除细胞碎片,以及受损或凋亡的细胞。巨噬细胞的表型和功能转变是一个动态过程,在TME各种刺激条件下可以极化为M1型和M2型两种主要亚群。在TME中,M1型巨噬细胞发挥抗肿瘤作用,有助于肿瘤免疫;而M2型巨噬细胞表现出强烈的免疫抑制表型,帮助肿瘤细胞增殖,进而促进骨转移发生。该文综述了巨噬细胞与TME间的相互作用,并探讨了巨噬细胞极化在前列腺癌、乳腺癌、肺癌等常见癌症骨转移中的作用,以及其对肿瘤发生和发展的影响。Bone metastasis is a common complication of many advanced cancers,especially prostate cancer(85%),breast cancer(70%)and lung cancer(40%),which severely affects the quality of life of the patients and increases its death risk.Macrophages are the essential immune cells in the human body that play a crucial role in the tumor microenvironment(TME),including phagocytosis or removal of cell debris,damaged or apoptotic cells.The phenotypic and functional transition of macrophages is a dynamic process.Under various stimulation conditions in TME,they can be transformed into two major subpopulations:M1 and M2.In TME,M1 macrophages exert anti-tumor effects and contribute to tumor immunity.M2 macrophages display a robust immunosuppressive phenotype,aiding in tumor cell proliferation and thereby promoting the occurrence of bone metastasis.This article reviews the interaction between macrophages and TME,and explores the role of macrophage polarization in bone metastasis of common cancers such as prostate cancer,breast cancer and lung cancer,and the influence in the occurrence and development of tumors.

关 键 词：骨转移 巨噬细胞极化 M1巨噬细胞 M2巨噬细胞 肿瘤微环境 

分 类 号：R730.3[医药卫生—肿瘤]