血管介入栓塞术治疗动脉瘤性蛛网膜下腔出血疗效及对患者血清高迁移率族蛋白B1、血清可溶性细胞间黏附因子-1、可溶性血管细胞黏附因子-1的影响  

Effect of Vascular Interventional Embolization on Aneurysmal Subarachnoid Hemorrhageand Its Influence on Serum HMGB1,sICAM-1 and sVCAM-1

作　　者：万腾 吴晓凡 李靖[1] WAN Teng;WU Xiaofan;LI Jing(Department of Neurosurgery,Huai’an Second People’s Hospital,Huai’an 200230,China)

机构地区：[1]淮安市第二人民医院神经外科,江苏淮安200230

出　　处：《陕西医学杂志》2025年第1期80-83,共4页Shaanxi Medical Journal

基　　金：江苏省自然科学基金资助项目(HD2022FE036)。

摘　　要：目的:探讨血管介入栓塞术治疗动脉瘤性蛛网膜下腔出血(aSAH)的疗效及对血清高迁移率族蛋白B1(HMGB1)、血清可溶性细胞间黏附因子-1(sICAM-1)、可溶性血管细胞黏附因子-1(sVCAM-1)的影响。方法:选择92例aSAH患者为研究目标,根据手术方法不同分为对照组(颅内动脉瘤夹闭术治疗)46例,观察组(血管介入栓塞术治疗)46例,比较两组手术前后免疫功能及sICAM-1、sVCAM-1、HMGB1水平变化,记录手术时间、并发症发生率、住院时间,并评估预后情况。结果:观察组手术时间、住院时间分别为(92.03±14.97)min、(18.73±4.41)d均短于对照组的手术时间(147.92±34.21)min,术后住院时间(23.35±4.15)d(均P<0.05);术后观察组免疫功能高于对照组(P<0.05);观察组术后HMGB1、sICAM-1、sVCAM-1水平低于对照组(均P<0.05);对照组不良反应总发生率高于观察组(P<0.05);对照组知期预后良好率低于观察组(P<0.05)。结论:血管介入栓塞术治疗aSAH手术耗时短、脑血管痉挛发生率低、免疫状态影响小,并可明降低血清HMGB1、sICAM-1、sVCAM-1水平。Objective:To investigate the efficacy of interventional embolization in the treatment of aneurysmal Subarachnoid hemorrhage(aSAH)and its effect on serum HMGB1,sICAM-1 and sVCAM-1.Methods:92 patients with aSAH were selected as the research target.According to the different surgical methods,46 patients were divided into the control group(intracranial aneurysm clipping treatment)and the observation group(vascular intervention embolization treatment).The immune function and serum levels of sICAM-1,sVCAM-1 and HMGB1were compared between the two groups before and after treatment The incidence of complications,length of hospital stay,and evaluation of prognosis.Results:Observation group operation time,length of hospital stay(92.03±14.97)min,respectively(18.73±4.41)d of operation time is shorter than control group(147.92±34.21)min,postoperative length of hospital stay(23.35±4.15)d(all P<0.05).Postoperative observation group of immune function is better than the control group(all P<0.05).Postoperative observation group HMGB1,sICAM-1,sVCAM-1 level is lower than the control group(all P<0.05).The control rate was 47.82%(22/46)is lower than the observation group good prognosis good prognosis rate was 69.59%(32/46)(all P<0.05).The control group 17.39%of the total incidence of 34.78%higher than in observation group(all P<0.05).Conclusion:Vascular interventional embolization for the treatment of a SAH has the advantages of short surgical time,low incidence of cerebral vasospasm,minimal impact on immune status,and can significantly reduce serum levels of HMGB1,sICAM-1,and sVCAM-1.

关 键 词：血管介入栓塞术 可溶性血管细胞黏附因子-1 颅内动脉瘤夹闭术 动脉瘤性蛛网膜下腔出血 可溶性细胞间黏附因子-1 高迁移率族蛋白B1 

分 类 号：R743[医药卫生—神经病学与精神病学]