升清降浊方联合常规西药治疗老年帕金森病疗效及对患者非运动症状的影响  

Curative effect of Shengqing Jiangzhuo decoction combined with routine western medicine and its influences on non-motor symptoms in elderly patients with Parkinson’s disease

作　　者：陈杨丽 赵彦青[2] 王伟民[3] CHEN Yangli;ZHAO Yanqing;WANG Weimin(Second Clinical Medicine,Henan University of Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南中医药大学第二临床医学院,河南郑州450002 [2]河南中医药大学第二临床医学院老年病科,河南郑州450002 [3]河南省中医院脑病科,河南郑州450002

出　　处：《陕西中医》2025年第1期64-67,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河南省卫生健康委员会科研项目(2022ZY1076)。

摘　　要：目的:探讨升清降浊方联合常规西药治疗老年帕金森病(气虚痰瘀证)疗效及对患者非运动症状的影响。方法:选取90例老年帕金森病患者,采用随机数表法将患者分为升清降浊组(n=45)和西药组(n=45),西药组患者采用常规西药治疗,升清降浊组采用升清降浊方联合常规西药治疗,两组患者均持续治疗1个月。记录两组治疗前后中医证候评分、帕金森病症状[采用统一帕金森病评定量表(UPDRS)评估]、非运动症状[采用非运动症状量表(NMSS)评估]、生活质量[采用帕金森病生活质量评分量表(PDQ)评估]和不良反应[采用精神症状评定-不良反应量表(TESS)评估]。结果:治疗后,升清降浊组患者的中医证候评分较西药组低,差异有统计学意义(P<0.05);升清降浊组患者的UPDRS、NMSS和PDQ量表评分较西药组低,差异有统计学意义(P<0.05)。治疗过程中,升清降浊组患者TESS量表评分中自主神经症状的不良反应评分较西药组低,差异有统计学意义(P<0.05)。结论:升清降浊方联合常规西药治疗可以改善气虚痰瘀型老年帕金森病患者中医证候和非运动症状,提高患者生活质量,降低不良反应发生情况。Objective:To explore the curative effect of Shengqing Jiangzhuo decoction combined with routine western medicine and its influences on non-motor symptoms in elderly patients with Parkinson’s disease(qi-deficiency phlegm stasis syndrome).Methods:A total of 90 elderly patients with Parkinson’s disease were divided into Shengqing Jiangzhuo group(n=45,Shengqing Jiangzhuo decoction+routine western medicine)and western medicine group(n=45,routine western medicine).All patients were treated for 1 month.The scores of TCM syndromes,Parkinson’s disease symptoms[Unified-Parkinson Disease Rating Scale(UPDRS)],non-motor symptoms[non-motor symptom scale(NMSS)],quality of life[Parkinson’s Disease Questionnaire(PDQ)]and adverse reactions[Treatment Emergent Symptom Scale(TESS)]in the two groups were recorded before and after treatment.Results:After treatment,scores of TCM syndromes in Shengqing Jiangzhuo group were lower than those in western medicine group(P<0.05),scores of UPDRS,NMSS and PDQ were lower than those in western medicine group(P<0.05).During treatment,TESS score in Shengqing Jiangzhuo group was lower than that in western medicine group(P<0.05).Conclusion:Shengqing Jiangzhuo decoction combined with routine western medicine can improve TCM syndromes,non-motor symptoms and quality of life,and reduce adverse reactions in elderly patients with Parkinson’s disease of qi-deficiency phlegm stasis syndrome.

关 键 词：老年帕金森病 升清降浊方 中医证候评分 气虚痰瘀证 非运动症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]