妊娠早期癫痫发作影响因素  

Influencing Factors of Seizures in Early Pregnancy

作　　者：徐勤荣 冯红选[1] 马博墩 侯晓夏 王媚瑕 董晓峰[1] 桂千 吴冠会[1] 程庆璋[1] 朱浩[1] 沈彦希 XU Qinrong;FENG Hongxuan;MA Bodun(Department of Neurology,Suzhou Hospital Affiliated to Nanjing Medical University,Jiangsu 215002,China)

机构地区：[1]南京医科大学附属苏州医院神经内科,215002 [2]南京中医药大学临床医学院,210023

出　　处：《医学研究杂志》2024年第11期123-126,共4页Journal of Medical Research

基　　金：江苏省苏州市“科教兴卫”青年科技项目(KJXW2023039);江苏省苏州市科技计划项目(医学应用基础研究)(SKY2023209);南京医科大学姑苏学院临床研究项目(GSKY20240203)。

摘　　要：目的 探讨妊娠早期癫痫发作相关的影响因素。方法 回顾性纳入2019年7月~2023年7月至南京医科大学附属苏州医院就诊的83例妊娠合并癫痫患者,按照妊娠早期是否有癫痫发作分为发作组(n=35)及非发作组(n=48),采用单因素和多因素Logistic回归分析探讨妊娠早期癫痫发作的影响因素,同时进一步采用受试者工作特征(receiver operating characteristic, ROC)曲线评估相关模型预测效能。结果 单因素分析结果显示,妊娠前9个月发作情况、妊娠前9个月发作频率、妊娠后是否调整治疗方案在两组间差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,妊娠前9个月发作情况、妊娠前9个月发作频率、妊娠后是否调整治疗方案与妊娠早期癫痫发作存在相关性(P<0.05)。据此构建的预测模型ROC曲线下面积为0.750(95%CI:0.652~0.858)。结论 妊娠前9个月发作情况和发作频率、妊娠后调整治疗方案与妊娠早期发作有关,据此构建的预测模型有一定的预测价值。Objective To investigate the related influencing factors of seizures in early pregnancy.Methods Patients with epilepsy and pregnancy in Suzhou Hospital Affiliated to Nanjing Medical University from July 2019 to July 2023 were retrospectively enrolled and divided into epileptic group(n=35)and non-epileptic group(n=48)according to whether they had epilepsy in early pregnancy.Univariate and multivariate Logistic regression models were used to analyze the influencing factors of seizures in early pregnancy.And the receiver operating characteristic(ROC)curve was further used to evaluate the predictive efficiency of the relevant models.Results Univariate analysis showed that there were statistically significant differences in the occurrence of seizures,frequency of seizures in 9months before pregnancy and whether adjusted treatment plan after pregnancy between epileptic group and non-epileptic group(P<0.05).Multivariate Logistic regression analysis showed that the occurrence of seizures,the frequency of seizures in 9months before pregnancy,and the whether adjusted treatment plan after pregnancy were correlated with seizures in early pregnancy(P<0.05).The area under the ROC curve of the predicted model was 0.750(95%CI:0.652-0.858)based on the results of multivariate Logistic regression analysis.Conclusion The occurrence of seizures,the frequency of seizures in 9months before pregnancy and whether adjusted treatment plan after pregnancy are related to the onset of seizures in early pregnancy.The prediction model established according to the results of multivariate Logistic regression analysis has some predictive value.

关 键 词：妊娠早期 癫痫 影响因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]