HPV-DNA联合肿瘤标志物检测在宫颈癌诊断中应用价值探析  

Exploration of the application value of HPV-DNA combined with tumor marker detection in the diagnosis of cervical cancer

作　　者：曹智善 陈海婷 Cao Zhishan;Chen Haiting(Tongji Hospital Affiliated to Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430000,China)

机构地区：[1]华中科技大学同济医学院附属同济医院,湖北武汉430000

出　　处：《首都食品与医药》2024年第24期89-91,共3页Capital Food Medicine

摘　　要：目的研究人乳头状瘤病毒(HPV)-DNA联合肿瘤标志物检测在宫颈癌诊断中的应用价值。方法通过回顾性分析,选择我院在2023年3月-2024年3月期间收治的疑似宫颈癌患者120例,将其作为观察组,选择同期到我院进行健康体检的健康体检者120例,将其作为对照组,检测两组受检者的肿瘤标志物,即CA125、CA153、CA199、CEA,对上述指标进行比较;然后实施HPV-DNA检查,将病理检查作为诊断的金标准,对观察组应用单纯HPV-DNA检测、单纯肿瘤标志物检测、联合检测下的宫颈癌诊断结果进行统计,对比三种方式对于宫颈癌的诊断效能。结果观察组患者的CA125、CA153、CA199、CEA水平高于对照组(P<0.05);病理检查观察组患者,阳性患者共86例,阴性患者共34例,单纯HPV-DNA技术检查下,阳性患者例数为82例,阴性患者例数为38例,单纯肿瘤标志物检测下,阳性患者例数为81例,阴性患者例数为39例;两种检测项目联合应用下,阳性患者例数85例,阴性患者例数为35例;联合检查的诊断效能高于单纯HPV-DNA技术检查和单纯肿瘤标志物检测,差异有统计学意义(P<0.05),但单纯HPV-DNA技术检查的诊断效能和单纯肿瘤标志物检测相比,差异无统计学意义(P>0.05)。结论宫颈癌诊断过程中应用HPV-DNA联合肿瘤标志物检测,可获得良好的诊断效能,肿瘤标志物水平会明显升高,应用价值高,值得推广。Objective To study the application effect of human papillomavirus(HPV)-DNA combined with tumor markers in the diagnosis of cervical cancer.Methods 120 patients with suspected cervical cancer in our hospital from March 2023 to March 2024 were selected as the observation group,and 120 healthy people who came to our hospital for physical examination in the same period were selected as the control group.The tumor markers of the two groups were detected,namely CA125,CA153,CA199 and CEA,and the above indexes were compared.Then,HPV-DNA examination was carried out,and pathological examination was taken as the gold standard.The diagnosis results of cervical cancer in the observation group were counted by using pure HPV-DNA detection,simple tumor marker detection and combined detection,and the diagnostic efficiency of the three detection methods for cervical cancer was evaluated.Results The levels of CA125,CA153,CA199 and CEA in the observation group were higher than those in the control group(P<0.05).In the pathological examination observation group,there were 86 positive patients and 34 negative patients.Under the simple HPV-DNA technique,there were 82 positive patients and 38 negative patients.Under the simple tumor marker detection,there were 81 positive patients and 39 negative patients.Under the combined examination technique,85 cases were positive and 35 cases were negative.The diagnostic efficiency of combined examination is higher than that of simple HPV-DNA technique examination and simple tumor marker examination,and the difference is statistically significant(P<0.05),but there is no statistical difference between the diagnostic efficiency of simple HPV-DNA technique examination and simple tumor marker examination(P>0.05).Conclusion The application of HPV-DNA combined with tumor markers in the diagnosis of cervical cancer can achieve good diagnostic efficiency,and the level of tumor markers will increase significantly,which is of high application value and worth popularizing.

关 键 词：人乳头瘤病毒-DNA 肿瘤标志物 宫颈癌 诊断价值 

分 类 号：R737.33[医药卫生—肿瘤]