基于SDF-1/CXCR4信号通路探讨醒脑静注射液联合尼莫地平促进高血压脑出血患者神经功能恢复的作用研究  

Exploring the Effect of Xingnaojing Injection Combined with Nimodipine on the Recovery of Neurological Function in Patients with Hypertensive Intracerebral Hemorrhage Based on SDF-1/CXCR4 Signaling Pathway

作　　者：褚秀丽[1] 张琳[2] 丁军 曹合利 徐晨[2] CHU Xiu-li;ZHANG Lin;DING Jun;CAO He-li;XU Chen(Department of Internal Medicine-Neurology,The Sixth People's Hospital to Shanghai Jiao Tong University School of Medicine,Shanghai,200233,China;Department of Neurosurgery,The Sixth People's Hospital to Shanghai Jiao Tong University School of Medicine,Shanghai,200233,China)

机构地区：[1]上海交通大学医学院附属第六人民医院神经内科,上海200233 [2]上海交通大学医学院附属第六人民医院神经外科,上海200233

出　　处：《现代生物医学进展》2024年第22期4224-4226,4239,共4页Progress in Modern Biomedicine

基　　金：上海市科委科技创新行动计划项目(19411968100)。

摘　　要：目的:基于基质细胞衍生因子-1(SDF-1)/CXC趋化因子受体4(CXCR4)信号通路,探讨醒脑静注射液联合尼莫地平促进高血压脑出血(HICH)患者神经功能恢复的作用。方法:采用随机数字表法将132例HICH患者分为对照组(接受尼莫地平治疗,66例)和研究组(对照组基础上接受醒脑静注射液治疗,66例)。对比两组血清神经细胞因子指标、血清SDF-1、CXCR4水平、脑卒中患者生活质量疾病专用量表(SIS)评分、美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分的变化情况。结果:治疗14 d后,两组血清神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)、神经胶质纤维酸性蛋白(GFAP)、SDF-1、CXCR4水平均下降,且研究组下降更为明显(P<0.05)。治疗3个月后,两组NIHSS、mRS评分均下降,且研究组改善幅度更大(P<0.05);两组SIS各维度评分均升高,且研究组改善幅度更大(P<0.05)。结论:醒脑静注射液联合尼莫地平可显著改善HICH患者预后,促进神经功能恢复,其作用机制可能与调控SDF-1/CXCR4信号通路有关。Objective:Based on the stromal cell-derived factor-1(SDF-1)/CXC chemokine receptor 4(CXCR4)signaling pathway,to investigate the effect of xingnaojing injection combined with nimodipine on the recovery of neurological function in patients with hypertensive intracerebral hemorrhage(HICH).Methods:Using a random number table method,132 patients with HICH were divided into control group(treated with nimodipine,66 cases)and research group(treated with xingnaojing injection on the basis of control group,66 cases).The changes of serum nerve cell factor indexes,serum SDF-1,CXCR4 levels,quality of life disease scale(SIS)score,national institutes of health stroke scale(NIHSS)score and modified Rankin scale(mRS)score were compared in two groups.Results:After 14 days of treatment,the levels of serum neuron-specific enolase(NSE),myelin basic protein(MBP),glial fibrillary acidic protein(GFAP),SDF-1 and CXCR4 in two groups decreased,and the decrease was more significant in the research group(P<0.05).After 3 months of treatment,the NIHSS and mRS scores in two groups decreased,and research group improved more significantly(P<0.05).The scores of SIS in each dimension in two groups increased,and research group improved more significantly(P<0.05).Conclusion:Xingnaojing injection combined with nimodipine can significantly improve the prognosis of HICH patients,and promote the recovery of neurological function,the mechanism may be related to the regulation of SDF-1/CXCR4 signaling pathway.

关 键 词：高血压脑出血 SDF-1/CXCR4信号通路 醒脑静注射液 尼莫地平 神经功能 

分 类 号：R-33[医药卫生] R743.34