卵巢癌患者肿瘤细胞减灭术行肠切除术后发生肠瘘的影响因素分析及预测模型建立  

Analysis of Influencing Factors and Prediction Model Establishment of Intestinal Fistula after Intestinal Resection in Ovarian Cancer Patients undergoing Cytoreductive Surgery

作　　者：吴寒舒 陈川 彭影 谢珍 王莹莹[1] WU Han-shu;CHEN Chuan;PENG Ying;XIE Zhen;WANG Ying-ying(Department of Gynaecology and Obstetrics,The First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei,Anhui,230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)妇产科,安徽合肥230001

出　　处：《现代生物医学进展》2024年第22期4250-4252,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(82303588)。

摘　　要：目的:探讨卵巢癌肿瘤细胞减灭术行肠切除术后发生肠瘘的影响因素。方法:89例卵巢癌肿瘤细胞减灭术行肠切除术患者根据术后是否并发肠瘘分为肠瘘组(n=16)和无肠瘘组(n=73)。多因素Logistic回归模型分析影响因素。受试者工作特征(ROC)曲线分析预测价值。结果:89例行卵巢癌肿瘤细胞减灭术行肠切除术的患者中发生肠瘘16例,肠瘘发生率为17.98%。体质量指数(BMI)≥24 kg/m^(2)、术前糖类抗原125(CA125)升高、腹水量升高、手术复杂性评分升高、术中出血量升高是影响卵巢癌肿瘤细胞减灭术患者行肠切除术后发生肠瘘的独立危险因素(P<0.05)。术前白蛋白升高为保护因素(P<0.05)。ROC分析结果显示,联合检测的预测效能较单一指标检测更佳。结论:BMI、CA125、腹水量、术中出血量、手术复杂性评分、术前白蛋白为患者术后发生肠瘘的影响因素,且联合检测的预测效能较单一指标检测更佳。Objective:To investigate the influencing factors of intestinal fistula after intestinal resection of ovarian cancer cytoreductive surgery.Methods:89 patients were divided into intestinal fistula group(n=16)and non-intestinal fistula group(n=73)according to whether postoperative intestinal fistula.The influencing factors was analyzed by univariate and multivariate Logistic regression models.The predictive value was analyzed by receiver operating characteristic(ROC)curve.Results:There were 16 cases intestinal fistula in 89 patients undergoing ovarian cancer cytoreductive surgery for intestinal resection,and the incidence of intestinal fistula was 17.98%.body mass index(BMI)≥24 kg/m^(2),elevated preoperative carbohydrate antigen 125(CA125),ascites volume,surgical complexity score,and intraoperative blood loss were independent risk factors for affecting intestinal fistula after intestinal resection in ovarian cancer cytoreductive surgery patients(P<0.05).And elevated preoperative albumin was a protective factor(P<0.05).The results of ROC analysis showed that,the predictive efficacy of combined detection was better than that of single indicator.Conclusion:BMI,CA125,abdominal water volume,intraoperative blood loss,surgical complexity score and preoperative albumin were the influencing factors for postoperative intestinal fistula,and the combined detection had better predictive efficacy than single detection.

关 键 词：卵巢癌 肿瘤细胞减灭术 肠切除 肠瘘 影响因素 

分 类 号：R737.31[医药卫生—肿瘤]