血清miR-202、miR-34a表达与原发性肝癌患者TACE术后发生医院感染的临床研究  

Clinical Study on the Expression of Serum miR-202 and miR-34a and Nosocomial Infection in Patients with Primary Liver Cancer after TACE

作　　者：张嘉诚 王金文 杜鹏 蒋富强 解鹏 张哲 杨剑 马军朋 ZHANG Jia-cheng;WANG Jin-wen;DU Peng;JIANG Fu-qiang;XIE Peng;ZHANG Zhe;YANG Jian;MA Jun-peng(Interventional Group of Radiology Diagnosis Department,The Sixth Medical Center of the General Hospital of the Chinese People's Liberation Army,Beijing,100048,China;Department of Geriatrics,Xiyuan Hospital of the Chinese Academy of Traditional Chinese Medicine,Beijing,100048,China)

机构地区：[1]中国人民解放军总医院第六医学中心放射诊断科介入组,北京100048 [2]中国中医科学院西苑医院老年科,北京100048

出　　处：《现代生物医学进展》2024年第22期4262-4264,共3页Progress in Modern Biomedicine

基　　金：北京市科学技术委员会"首都临床特色应用研究"项目(Z171100000417049)。

摘　　要：目的:分析血清微小核糖核酸(miR)-202、miR-34a表达与原发性肝癌(PLC)患者行肝动脉灌注化疗栓塞术(TACE)术后发生医院感染的关系。方法:选取接受TACE术的975例PLC患者,按照TACE术后是否发生医院感染分为感染组(n=80)、未感染组(n=895),对比两组患者血清miR-202、miR-34a相对表达量及临床资料,多因素Logistic回归模型分析影响因素,受试者工作特征(ROC)曲线分析预测价值。结果:年龄≥60岁、合并糖尿病、合并腹水、介入操作时间≥120 min、未预防性使用抗菌药物是影响PLC患者TACE术后医院感染的危险因素(P<0.05),血清miR-202、miR-34a相对表达量上升是保护因素(P<0.05)。血清miR-202、miR-34a二者联合预测PLC患者TACE术后医院感染高于单一预测。结论:PLC患者TACE术后医院感染患者血清miR-202、miR-34a呈低表达,且二者联合可有效预测TACE术后医院感染的发生。Objective:To analyze the relationship between serum microRNA(miR)-202,miR-34a expression and nosocomial infection in patients with primary liver cancer(PLC)after transcatheter arterial chemoembolization(TACE).Methods:975 patients with PLC who underwent TACE were selected.Patients were divided into infection group(n=80)and uninfected group(n=895)according to whether nosocomial infection occurred after TACE,the relative expression levels of serum miR-202 and miR-34a and clinical data were compared between two groups,the influencing factors were analyzed by multivariate Logistic regression model,the value of were analyzed by receiver operating characteristic(ROC)curve.Results:The age≥60 years old,diabetes mellitus,ascites,interventional operation time≥120 min,and non-prophylactic use of antibiotics were risk factors for nosocomial infection in patients with PLC after TACE(P<0.05),the increase in the relative expression of serum miR-202 and miR-34a were protective factor(P<0.05).The combined prediction of serum miR-202 and miR-34a for postoperative nosocomial infection in PLC patients with TACE was higher than that of single prediction.Conclusion:The expression of serum miR-202 and miR-34a in patients with PLC after TACE are low,and their combination can effectively predict the occurrence of nosocomial infection after TACE.

关 键 词：原发性肝癌 miR-202 MIR-34A 肝动脉灌注化疗栓塞术 医院感染 

分 类 号：R735.7[医药卫生—肿瘤]