血清BDNF、IGF-1及CysC水平与帕金森病患者自主神经功能障碍的关系研究  

Study on the Relationship between Serum BDNF,IGF-1 and CysC Levels and Autonomic Nerve Dysfunction in Patients with Parkinson's Disease

作　　者：刘丽娟 康涛 王卫婵 卫婧雅 杜芳 LIU Li-juan;KANG Tao;WANG Wei-chan;WEI Jing-ya;DU Fang(Department of Neurology,The First Affiliated Hospital of Air Force Military Medical University,Xi'an,Shaanxi,710000,China)

机构地区：[1]空军军医大学第一附属医院神经内科,陕西西安710000

出　　处：《现代生物医学进展》2024年第22期4268-4270,共3页Progress in Modern Biomedicine

基　　金：陕西省自然科学基础研究计划项目(2020JM-338)。

摘　　要：目的:研究血清脑源性神经营养因子(BDNF)、胰岛素样生长因子(IGF)-1及胱抑素C(Cys C)水平与帕金森病(PD)患者自主神经功能障碍的关系。方法:188例PD患者根据是否发生自主神经功能障碍分为自主神经功能障碍组(n=63)、非自主神经功能障碍组(n=125)。另选取健康志愿者140例为对照组。比较三组BDNF、IGF-1水平。采用多因素Logistic回归分析影响因素。结果:对照组、非自主神经功能障碍组、自主神经功能障碍组BDNF、IGF-1水平依次下降,Cys C水平依次升高(P<0.05)。血清BDNF、IGF-1低水平、血清Cys C高水平、SSR异常、H-Y分期2.5~4期是PD患者自主神经功能障碍的危险因素(P<0.05)。结论:血清BDNF、IGF-1低水平及Cys C高水平促进PD患者自主神经功能障碍的发生发展。Objective:To study the relationship between serum brain-derived neurotrophic factor(BDNF),insulin-like growth factor(IGF)-1 and cystatin C(CysC)levels and autonomic nerve dysfunction in patients with Parkinson's disease(PD).Methods:188 PD patients were divided into autonomic nerve dysfunction group(n=63)and non-autonomic nerve dysfunction group(n=125)according to the occurrence of autonomic nerve dysfunction,and 140 healthy volunteers were selected as the control group.the levels of BDNF and IGF-1 among three groups were compared.The influencing factors was analyzed by multivariate Logistic regression analysis.Results:The BDNF,IGF-1 levels in control group,non-autonomic nerve dysfunction group and autonomic nerve dysfunction group decreased in turn,and the CysC level increased in turn(P<0.05).Low serum BDNF,IGF-1 levels,high serum CysC level,abnormal SSR,and H-Y stage 2.5~4 were risk factors for autonomic dysfunction in PD patients(P<0.05).Conclusion:The low serum BDNF,IGF-1 levels and high CysC level promote the occurrence and development of autonomic nerve dysfunction in PD patients.

关 键 词：脑源性神经营养因子 胰岛素样生长因子-1 胱抑素C 帕金森病 自主神经功能障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]