不同危险度分型急性淋巴细胞白血病患儿血清OPN、HGF的变化及其与预后的关系分析  

Analysis of Changes in Serum OPN and HGF Levels and Their Relationship with Prognosis in Children with Acute Lymphoblastic Leukemia of Different Risk Classification

作　　者：刘英杰 张凝 万科成 陈远禄 周潮艾 冯小伟 LIU Ying-jie;ZHANG Ning;WAN Ke-cheng;CHEN Yuan-lu;ZHOU Chao-ai;FENG Xiao-wei(Department of Pediatrics,Hainan Hospital Affiliated to Hainan Medical University/Hainan Provincial People's Hospital,Haikou,Hainan,570311,China)

机构地区：[1]海南医学院附属海南医院/海南省人民医院儿科,海南海口570311

出　　处：《现代生物医学进展》2024年第22期4278-4280,4392,共4页Progress in Modern Biomedicine

基　　金：海南省卫生健康行业科研项目(20A200091)。

摘　　要：目的:研究不同危险度分型急性淋巴细胞白血病(ALL)患儿血清骨桥蛋白(OPN)、肝细胞生长因子(HGF)的变化及其与预后的关系。方法:选择160例ALL患儿。根据患儿的危险度分型分为低危(LR)组(n=74)、中危(IR)组(n=55)和高危(HR)组(n=31)。对比不同危险度分型患儿血清OPN、HGF水平。依据不同危险度进行规范化治疗,随访1年,根据患儿的预后情况分为预后不良组和预后良好组。多因素Logistic回归分析ALL患儿预后不良的影响因素。结果:IR组和HR组患儿血清OPN、HGF水平较LR组更高,且HR组较IR组更高(P<0.05)。随访1年,ALL患儿预后不良发生率为27.50%。预后不良组血清OPN、HGF水平较预后良好组更高(P<0.05)。多因素的Logistic回归分析发现,危险度分型为高危、OPN和HGF升高是ALL患儿预后不良的危险因素(P<0.05)。结论:ALL患儿血清OPN、HGF水平升高,与危险度分型有关,且危险度分型为高危、OPN和HGF升高是ALL患儿预后不良的危险因素。Objective:To study the changes of serum osteopontin(OPN)and hepatocyte growth factor(HGF)in children with different risk classification of acute lymphoblastic leukemia(ALL)and their relationship with prognosis.Methods:160 children with ALL were selected.Patients were divided into low risk(LR)group(n=74),intermediate risk(IR)group(n=55)and high risk(HR)group(n=31)according to the risk classification.The levels of serum OPN and HGF in children with different risk classification were compared.Standardized treatment was carried out according to different risk degrees,follow-up 1 year,children were divided into poor prognosis group and good prognosis group according to their prognosis.The influencing factors of poor prognosis in children with ALL were analyzed by multivariate Logistic regression analysis.Results:The levels of serum OPN and HGF in IR group and HR group were higher than those in LR group,and those in HR group were higher than those in IR group(P<0.05).Follow-up 1 year,the incidence of poor prognosis in children with ALL was 27.50%.The serum levels of OPN and HGF in poor prognosis group were higher than those in good prognosis group(P<0.05).Multivariate Logistic regression analysis showed that,high risk classification,elevated OPN and HGF were risk factors for poor prognosis in children with ALL(P<0.05).Conclusion:The levels of serum OPN and HGF in children with ALL were increased,which are related to the risk classification.High risk classification,elevated OPN and HGF are risk factors for poor prognosis in children with ALL.

关 键 词：危险度分型 急性淋巴细胞白血病 骨桥蛋白 肝细胞生长因子 预后 

分 类 号：R733.7[医药卫生—肿瘤]