基于TLR4/NF-κB信号通路探讨加味补中益气汤联合四联疗法治疗Hp阳性慢性萎缩性胃炎的疗效及其机制  

Explore the Efficacy and Mechanism of Jiawei Buzhong Yiqi Decoction Combined with Quadruple Therapy in the Treatment ofHp Positive Chronic Atrophic Gastritis Based on TLR4/NF-κB Signaling Pathway

作　　者：舒晓霞 廖安 张洁 刘乐鑫 王星儒 SHU Xiao-xia;LIAO An;ZHANG Jie;LIU Le-xin;WANG Xing-ru(Department of Spleen and Stomach Diseases,Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine(Futian),Shenzhen,Guangdong,518000,China)

机构地区：[1]广州中医药大学深圳医院(福田)脾胃病科,广东深圳518000

出　　处：《现代生物医学进展》2024年第22期4302-4304,共3页Progress in Modern Biomedicine

基　　金：广东省医学会临床科研专项基金项目(A202302016)。

摘　　要：目的:基于Toll样变体4(TLR4)/核因子κB(NF-κB)信号通路探讨加味补中益气汤联合四联疗法治疗幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)的疗效及其机制。方法:138例Hp阳性CAG患者随机分为对照组(四联疗法治疗,69例)和研究组(加味补中益气汤联合四联疗法治疗,69例)。对比两组中医证候积分、Hp根除率、血清胃肠激素、血清胃蛋白酶原(PG)和TLR4/NF-κB信号通路相关指标。结果:研究组治疗后Hp根除率高于对照组,主症、次症、总分低于对照组(P<0.05)。治疗后,研究组胃泌素(GAS)、PGⅡ低于对照组,胃动素(MTL)、PGⅠ高于对照组(P<0.05)。研究组治疗后TLR4信使核糖核酸(mRNA)、NF-κB mRNA表达低于对照组(P<0.05)。结论:加味补中益气汤联合四联疗法治疗Hp阳性CAG患者,可有效改善临床症状,提高Hp根除率,调节血清胃肠激素和PG水平,发挥疗效的作用机制可能与调节TLR4/NF-κB信号通路有关。Objective:Base on Toll-like variant 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathway to explore the efficacy and mechanism of jiawei buzhong yiqi decoction combine with quadruple therapy in the treatment of Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods:138 Hp positive CAG patients were randomly divided into control group(treated with quadruple therapy,69 cases)and study group(treated with jiawei buzhong yiqi decoction combined with quadruple therapy,69 cases).The traditional chinese medicine syndrome points,Hp eradication rate,serum gastrointestinal hormones,serum pepsinogen(PG)and TLR4/NF-κB signaling pathway related indicators were compared between two groups.Results:Hp eradication rate in study group was higher than that in control group after treatment,and the main symptoms,secondary symptoms and total scores were lower than those in control group(P<0.05).After treatment,Gastrin(GAS),PGII in study group was lower than that in control group and motilin(MTL),PGI was higher than that in control group(P<0.05).TLR4 messenger RNA(mRNA)and NF-κB mRNA expression in study group were lower than those in control group after treatment(P<0.05).Conclusion:Jiawei buzhong yiqi decoction combine with quadruple therapy in the treatment of Hp positive CAG patients,which can effectively improve clinical symptoms and improve Hp eradication rate,regulate serum gastrointestinal hormones and PG levels.The mechanism of efficacy may be related to the regulation of TLR4/NF-κB signaling pathway.

关 键 词：TLR4/NF-κB信号通路 加味补中益气汤 四联疗法 HP阳性 慢性萎缩性胃炎 

分 类 号：R573.32[医药卫生—消化系统]