脑脊液TREM-1、MCP-1与动脉瘤性蛛网膜下腔出血患者手术治疗转归的关系  

Relationship between TREM-1 and MCP-1 in Cerebrospinal Fluid and the Outcome of Surgical Treatment in Patients with Aneurysmal Subarachnoid Hemorrhage

作　　者：刘雪龙 刘展[1] 王艮卫[1] 陶胜忠[1] 尹梦磊 LIU Xue-long;LIU Zhan;WANG Gen-wei;TAO Sheng-zhong;YIN Meng-lei(Department of Neurosurgery,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,450000,China)

机构地区：[1]郑州大学第二附属医院神经外科,河南郑州450000

出　　处：《现代生物医学进展》2024年第22期4305-4307,4366,共4页Progress in Modern Biomedicine

基　　金：河南省医学科技攻关计划项目(RKX202202032)。

摘　　要：目的:探讨脑脊液髓样细胞触发受体-1(TREM-1)、单核细胞趋化蛋白-1(MCP-1)与动脉瘤性蛛网膜下腔出血(aSAH)患者手术治疗转归的关系。方法:选择294例aSAH患者,术前检测脑脊液TREM-1、MCP-1水平。出院后随访3个月,采用改良Rankin量表(m RS)评估患者预后,并据此将患者分为转归不良组(103例)和转归良好组(191例)。多因素Logistic回归分析影响aSAH术后转归不良的因素。结果:转归不良组脑脊液TREM-1、MCP-1水平均高于转归良好组(P<0.05)。Hunt-Hess分级Ⅲ~Ⅳ级、并发迟发性脑缺血、TREM-1升高、MCP-1升高是aSAH术后转归不良的危险因素(P<0.05)。结论:aSAH术后转归不良患者血清TREM-1、MCP-1水平升高,是aSAH术后转归不良的危险因素。Objective:To investigate the relationship between triggering receptor expressed on myeloid cells-1(TREM-1)and monocyte chemoattractant protein-1(MCP-1)in cerebrospinal fluid and the outcome of surgical treatment in patients with aneurysmal subarachnoid hemorrhage(aSAH).Methods:294 patients with aSAH were selected,the levels of TREM-1 and MCP-1 in cerebrospinal fluid were detected before operation.3 months after discharge,patient outcomes were assessed using the modified Rankin scale(mRS),and patients were divided into poor outcome group(103 cases)and good outcome group(191 cases)according to this.The factors affecting the poor outcome after aSAH were analyzed by multivariate logistic regression analysis.Results:The levels of TREM-1 and MCP-1 in cerebrospinal fluid in poor outcome group were higher than those in good outcome group(P<0.05).Hunt-Hess grade Ⅲ~Ⅳ,delayed cerebral ischemia,increased TREM-1 and MCP-1 were risk factors for poor outcome after aSAH(P<0.05).Conclusion:The increase of serum TREM-1 and MCP-1 levels in patients with poor outcome after aSAH are risk factor for poor outcome after aSAH.

关 键 词：动脉瘤性蛛网膜下腔出血 髓样细胞触发受体-1 单核细胞趋化蛋白-1 术后转归 

分 类 号：R743.35[医药卫生—神经病学与精神病学]