血清睾酮、PON-1、PKM2与子宫内膜癌患者临床病理特征和预后的关系  

Relationship between Serum Testosterone,PON-1,PKM2 and Clinicopathological Features and Prognosis of Endometrial Cancer Patients

作　　者：汪佳玲 张静娟 陈舒月 张靖文 王小雨 冯文 WANG Jia-ling;ZHANG Jing-juan;CHEN Shu-yue;ZHANG Jing-wen;WANG Xiao-yu;FENG Wen(Department of Gynaecology,Lianyungang Hospital Affiliated to Xuzhou Medical University,Lianyungang,Jiangsu,222000,China;Graduate School of Jinzhou Medical University,Jinzhou,Liaoning,121001,China;Lianyungang Clinical Medical College of Nanjing Medical University,Lianyungang,Jiangsu,222000,China)

机构地区：[1]徐州医科大学附属连云港医院妇科,江苏连云港222000 [2]锦州医科大学研究生院,辽宁锦州121001 [3]南京医科大学连云港临床医学院,江苏连云港222000

出　　处：《现代生物医学进展》2024年第22期4308-4310,4381,共4页Progress in Modern Biomedicine

基　　金：江苏省妇幼健康科研项目(F201669)。

摘　　要：目的:探讨血清睾酮(T)、对氧磷酶-1(PON-1)、丙酮酸激酶M2(PKM2)与子宫内膜癌(EC)患者临床病理特征和预后的关系。方法:收集120例EC患者的临床资料,分析血清T、PON-1、PKM2与EC患者临床病理特征的关系;绘制K-M生存曲线分析3年总生存率(OS);Cox比例风险模型分析影响因素。结果:肌层浸润≥1/2、有淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阳性、国际妇产科联盟(FIGO)分期为Ⅲ-Ⅳ期的血清T及PKM2水平较肌层浸润<1/2、无淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阴性、FIGO分期为Ⅰ-Ⅱ期更高,而PON-1则相对更低(P<0.05)。EC患者血清T及PKM2低水平,PON-1高水平的3年OS较血清T及PKM2高水平,PON-1低水平更高(P<0.05)。Cox比例风险模型分析显示,腹腔积液亦或是肿瘤细胞冲洗液阳性、血清T高水平、PON-1低水平及PKM2高水平是EC患者不良预后的危险因素。结论:血清T、PKM2高水平,PON-1低水平与EC患者的肌层浸润、淋巴结转移、腹腔积液亦或是肿瘤细胞冲洗液阳性、FIGO分期Ⅲ-Ⅳ期及不良预后有关,EC患者不良预后的危险因素包括腹腔积液亦或是肿瘤细胞冲洗液阳性、血清T高水平、PON-1低水平及PKM2高水平。Objective:To investigate the relationship between serum testosterone(T),paraoxonase-1(PON-1),pyruvate kinase M2(PKM2)and clinicopathological features and prognosis of endometrial carcinoma(EC)patients.Methods:The clinical data of 120 EC patients were collected.The relationship between serum T,PON-1,PKM2 and clinicopathological features of EC patients was analyzed.The 3-year overall survival(OS)was analyzed by drawn K-M survival curve.The prognostic factors of EC patients were analyzed by Cox proportional hazard model.Results:The levels of serum T and PKM2 in patients with myometrial invasion≥1/2,lymph node metastasis,ascites or tumor cell flushing fluid positive and International Federation of Gynecology and Obstetrics(FIGO)stage III-IV were higher than those in patients with myometrial invasion<1/2,no lymph node metastasis,ascites or tumor cell flushing fluid negative and FIGO stage Ⅰ-Ⅱ,while PON-1 was relatively lower(P<0.05).The 3-year OS of EC patients with high PON-1 level was higher than that of EC patients with high serum T and PKM2 levels,and the low level of PON-1 was higher(P<0.05).Cox proportional hazard model analysis showed that,ascites or tumor cell flushing fluid positive,high serum T level,low PON-1 level and high PKM2 level were risk factors for poor prognosis in EC patients.Conclusion:High levels of serum T,PKM2,and low levels of PON-1 are associate with myometrial invasion,lymph node metastasis,ascites or tumor cell flushing fluid positive,FIGO stage Ⅲ-Ⅳ and poor prognosis in EC patients,risk factors for poor prognosis in EC patients include ascites or tumor cell flushing fluid positive,high levels of serum T,low levels of PON-1 and high levels of PKM2.

关 键 词：子宫内膜癌 睾酮 对氧磷酶-1 丙酮酸激酶M2 临床病理特征 预后 

分 类 号：R737.33[医药卫生—肿瘤]