半夏泻心汤对Hp阳性慢性萎缩性胃炎患者MAPK/ERK信号通路的影响  

Effect of Banxia Xiexin Decoction on MAPK/ERK Signaling Pathway in Patients withHp Positive Chronic Atrophic Gastritis

作　　者：张镕 郭洪波[2] 刘文涛 秦泽君 叶俊辰 ZHANG Rong;GUO Hong-bo;LIU Wen-tao;QIN Ze-jun;YE Jun-chen(The First Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi,030000,China;Department of Traditional Chinese Medicine,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi,030000,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030000 [2]山西医科大学第一医院中医科,山西太原030000

出　　处：《现代生物医学进展》2024年第22期4314-4316,共3页Progress in Modern Biomedicine

基　　金：全国名老中医药专家传承工作室建设项目[国中医药人教发(2016)42号]。

摘　　要：目的:观察半夏泻心汤对幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)患者丝裂原活化蛋白激酶(MAPK)/细胞外信号调节激酶(ERK)信号通路的影响。方法:将96例Hp阳性CAG患者随机分为对照组(常规四联治疗,48例)和观察组(半夏泻心汤联合常规四联治疗,48例)。对比两组疗效、Hp根除率、中医证候积分、胃蛋白酶原(PG)和MAPK/ERK信号通路相关指标。结果:观察组的临床总有效率、Hp根除率高于对照组(P<0.05)。治疗后,相较于对照组,观察组主症、次症、总分、PGⅡ、MEK1信使核糖核酸(mRNA)、MEK2mRNA、ERK1mRNA、ERK2mRNA表达更低,PGⅠ更高(P<0.05)。结论:半夏泻心汤治疗Hp阳性CAG患者,可提高临床治疗效果,改善临床症状和PG水平,调节外周血MAPK/ERK信号通路。Objective:To observe the effect of banxia xiexin decoction on mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase(ERK)signaling pathway in patients with Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).Methods:96 Hp positive CAG patients were randomly divided into control group(treated with conventional quadruple therapy,48 cases)and observation group(treated with banxia xiexin decoction combined with conventional quadruple,48 cases).The efficacy,Hp eradication rate,traditional chinese medicine syndrome points,pepsinogen(PG)and MAPK/ERK signaling pathway related indicators were compared between two groups.Results:The total clinical effective rate and Hp eradication rate in observation group were higher than that of the control group,respectively(P<0.05).After treatment,compared with control group,the main symptoms,secondary symptoms,total scores,PGII,the expression of MEK1 messenger ribonucleic acid(mRNA),MEK2 mRNA,ERK1 mRNA,and ERK2 mRNA in observation group were lower,and PGI was higher(P<0.05).Conclusion:Banxia xiexin decoction in the treatment of Hp positive CAG patients,which can improve the clinical treatment effect,improve the clinical symptoms and PG level,and regulate the MAPK/ERK signaling pathway in peripheral blood.

关 键 词：慢性萎缩性胃炎 半夏泻心汤 HP阳性 MAPK/ERK信号通路 

分 类 号：R573.32[医药卫生—消化系统] R242[医药卫生—内科学]