米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能及血清GLP-1和PYY水平的影响  

Effects of Aspergillus Oryzae Pancreatin Tablets on Intestinal Flora,Gastrointestinal Function and Serum GLP-1 and PYY Levels in Patients with Cirrhosis-Related Dyspepsia

作　　者：何汝 栗凤霞 郝瑞军 王红云[1] 王俊平[1] HE Ru;LI Feng-xia;HAO Rui-jun;WANG Hong-yun;WANG Jun-ping(Department of Gastroenterology,The Fifth Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi,030012,China)

机构地区：[1]山西医科大学第五临床医学院消化内科,山西太原030012

出　　处：《现代生物医学进展》2024年第22期4317-4319,共3页Progress in Modern Biomedicine

基　　金：山西省医学重点科研项目(2020XM23)。

摘　　要：目的:探讨米曲菌胰酶片对肝硬化相关消化不良患者肠道菌群、胃肠功能及血清胰高糖素样肽-1(GLP-1)和酪酪肽(PYY)水平的影响。方法:将我院129例肝硬化相关消化不良患者随机分为对照组(肝硬化常规治疗,n=64)和实验组(在对照组的基础上接受米曲菌胰酶片治疗,n=65)。对比两组消化不良症状积分、肠道菌群指标、胃肠功能指标、血清GLP-1和PYY水平、生活质量变化情况。结果:实验组治疗第4周后消化不良症状积分、肠球菌、肠杆菌数量、GLP-1、PYY水平和NDI评分低于对照组,双歧杆菌、乳酸杆菌数量、胃排空率、胃运动指数、胃收缩频率、肠蠕动频率高于对照组(P<0.05)。结论:米曲菌胰酶片通过促进肠道菌群平衡、改善胃肠功能、调节血清GLP-1和PYY水平,可减轻肝硬化患者的消化不良症状,改善患者的生活质量。Objective:To investigate the effects of aspergillus oryzae pancreatin tablets on intestinal flora,gastrointestinal function and serum glucagon-like peptide-1(GLP-1)and casein peptide(PYY)levels in patients with cirrhosis-related dyspepsia.Methods:According to the random number table method,129 patients with liver cirrhosis-related dyspepsia who were treated in our hospital from March 2021 to December 2023 were divided into control group(routine treatment of liver cirrhosis,n=64)and experimental group(treated with aspergillus oryzae trypsin tablets on the basis of control group,n=65).The changes of dyspepsia symptom score,intestinal flora index,gastrointestinal function index,serum GLP-1 and PYY levels and quality of life were compared between two groups.Results:The scores of dyspepsia symptoms,the number of enterococcus,enterobacter,the levels of GLP-1,PYY and NDI score in experimental group were lower than that in control group 4 weeks after treatment,and the number of bifidobacteria,lactobacilli,the gastric emptying rate,gastric motility index,gastric contraction frequency and intestinal peristalsis frequency were higher than that in control group(P<0.05).Conclusion:Aspergillus oryzae pancreatin tablets by promoting the balance of intestinal flora,improving gastrointestinal function and regulating serum GLP-1 and PYY levels,which can alleviate the dyspepsia symptoms of patients with cirrhosis and improve the quality of life of patients.

关 键 词：米曲菌胰酶片 肝硬化 消化不良 肠道菌群 胃肠功能 胰高糖素样肽-1 酪酪肽 

分 类 号：R575.2[医药卫生—消化系统]