LncRNA SOCS2-AS1、miR-454-3p在人胃癌组织中的表达及临床意义  

Expression and Clinical Significance of LncRNA SOCS2-AS1 and miR-454-3p in Human Gastric Cancer Tissues

作　　者：许丽华 张允 仇俊兰 张怀 潘承祺 XU Li-hua;ZHANG Yun;QIU Jun-lan;ZHANG Huai;PAN Cheng-qi(Department of Oncology,Suzhou Hospital Affiliated to Medicine School of Nanjing University,Suzhou,Jiangsu,215000,China)

机构地区：[1]南京大学医学院附属苏州医院肿瘤内科,江苏苏州215000

出　　处：《现代生物医学进展》2024年第22期4327-4329,4297,共4页Progress in Modern Biomedicine

基　　金：江苏省科技厅社会发展-临床前沿技术项目(BE2018669)。

摘　　要：目的:探讨长链非编码核糖核酸(LncRNA)细胞因子信号转导抑制因子2-反义转录本1(SOCS2-AS1)、微小核糖核酸(miRNA)-454-3p在人胃癌组织中的表达及临床意义。方法:选取120例行胃癌根治术患者的胃癌组织和癌旁组织。检测上述组织中LncRNA SOCS2-AS1、miR-454-3p表达。分析LncRNA SOCS2-AS1、miR-454-3p表达与胃癌患者临床病理特征和预后的关系,多因素COX回归分析胃癌患者预后不良的影响因素。结果:胃癌组织中LncRNA SOCS2-AS1、miR-454-3p表达均低于癌旁组织(P<0.05)。LncRNA SOCS2-AS1、miR-454-3p表达与分化程度、浸润深度、淋巴结转移、TNM分期有关(P<0.05)。LncRNA SOCS2-AS1低表达组3年总生存率(OS)低于LncRNA SOCS2-AS1高表达组,miR-454-3p低表达组3年OS低于miR-454-3p高表达组(P<0.05)。发生淋巴结转移、TNM分期Ⅲ期是胃癌患者预后不良的危险因素(P<0.05),miR-454-3p、LncRNA SOCS2-AS1高表达是胃癌患者预后不良的保护因素(P<0.05)。结论:胃癌组织中LncRNA SOCS2-AS1、miR-454-3p呈低表达,二者与胃癌患者病理特征及预后不良密切相关。Objective:To investigate the expression and clinical significance of long non-coding ribonucleic acids(LncRNA)cytokine signal transduction inhibitor 2-antisense transcript 1(SOCS2-AS1)and micribonucleic acid(miRNA)-454-3p in human gastric cancer tissues.Methods:The gastric cancer tissues and adjacent tissues of 120 patients undergoing radical gastrectomy were selected.The expression of LncRNA SOCS2-AS1 and miR-454-3p in above-mentioned tissues were detected.After 3 years of follow-up,the relationship between the expression of LncRNA SOCS2-AS1,miR-454-3p and the clinical pathological characteristics and prognosis of gastric cancer patients by analysis,and the influencing factors of poor prognosis in gastric cancer patients were analyzed by multivariate COX regression.Results:The expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues was lower than that in adjacent tissues(P<0.05).The expression of LncRNA SOCS2-AS1 and miR-454-3p was related to the degree of differentiation,depth of invasion,lymph node metastasis and TNM stage(P<0.05).The 3-year overall survival(OS)in LncRNA SOCS2-AS1 low expression group was lower than that in LncRNA SOCS2-AS1 high expression group,and the 3-year OS in miR-454-3p low expression group was lower than that in miR-454-3p high expression group(P<0.05).Lymph node metastasis and TNM stage III were risk factors for poor prognosis in gastric cancer patients(P<0.05).High expression of miR-454-3p and LncRNA SOCS2-AS1 was a protective factor for poor prognosis in gastric cancer patients(P<0.05).Conclusion:The low expression of LncRNA SOCS2-AS1 and miR-454-3p in gastric cancer tissues is closely related to the pathological characteristics and poor prognosis of gastric cancer patients.

关 键 词：胃癌 LncRNA SOCS2-AS1 miR-454-3p 病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]