非小细胞肺癌组织MAGEA4、NY-ESO-1表达及其与临床病理特征和预后的关系  

Expression of MAGEA4 and NY-ESO-1 in Non-Small Cell Lung Cancer and Their Relationship with Clinicopathological Features and Prognosis

作　　者：刘平闯 张文辉 王迪 孙宜田 张灿堂 陈玉玲 LIU Ping-chuang;ZHANG Wen-hui;WANG Di;SUN Yi-tian;ZHANG Can-tang;CHEN Yu-ling(Graduate School of Xuzhou Medical University,Xuzhou,Jiangsu,221000,China;Department of Respiratory and Critical Care Medicine,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu,221000,China)

机构地区：[1]徐州医科大学研究生学院,江苏徐州221000 [2]徐州医科大学附属医院呼吸与危重症医学科,江苏徐州221000

出　　处：《现代生物医学进展》2024年第22期4333-4335,共3页Progress in Modern Biomedicine

基　　金：江苏省高校重点实验室开放课题(XZSYSKF2023018)。

摘　　要：目的:探讨非小细胞肺癌(NSCLC)组织黑素瘤相关抗原A4(MAGEA4)、纽约食管鳞状上皮癌抗原1(NY-ESO-1)表达与临床病理特征和预后的关系。方法:选取我院309例NSCLC患者,取手术切除的癌组织和癌旁组织检测MAGEA4和NY-ESO-1表达。比较不同临床病理特征NSCLC组织中MAGEA4、NY-ESO-1表达差异。随访3年,分析MAGEA4、NY-ESO-1表达与NSCLC患者预后的关系以及影响NSCLC患者预后的因素。结果:NSCLC癌组织MAGEA4、NY-ESO-1的阳性表达率高于癌旁组织(P<0.05)。NSCLC患者中MAGEA4、NY-ESO-1阳性表达率增高与低分化、TNM分期ⅢA期、淋巴结转移有关(P<0.05)。MAGEA4、NY-ESO-1阳性表达3年总生存(OS)率低于MAGEA4、NY-ESO-1阴性表达患者(P<0.05)。MAGEA4阳性表达、淋巴结转移、TNM分期ⅢA期、NY-ESO-1阳性表达是NSCLC患者不良预后的危险因素(P<0.05)。结论:NSCLC组织中MAGEA4和NY-ESO-1阳性表达率升高,与淋巴结转移、TNM分期ⅢA期、低分化和NSCLC患者不良预后有关。Objective:To investigate the relationship between the expression of melanoma-associated antigen A4(MAGEA4)and New York esophageal squamous cell carcinoma antigen 1(NY-ESO-1)in non-small cell lung cancer(NSCLC)tissues and clinicopathological features and prognosis.Methods:309 NSCLC patients in our hopital were selected,surgically resected cancer tissues and adjacent tissues were taken,the expression of MAGEA4 and NY-ESO-1 was detected.The expression differences of MAGEA4 and NY-ESO-1 in NSCLC tissues with different clinicopathological features were compared.Followed up for 3 years,the relationship between MAGEA4 and NY-ESO-1 expression and prognosis of NSCLC patients and the factors affecting prognosis of NSCLC patients were analyzed.Results:The positive expression rates ofMAGEA4 and NY-ESO-1 in NSCLC cancer tissues were higher than in adjacent tissues(P<0.05).The increased positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC patients were associated with low differentiation,TNM stageⅢA,and lymph node metastasis(P<0.05).The 3-year overall survival(OS)rate of MAGEA4,NY-ESO-1 positive expression was lower than that of MAGEA4,NY-ESO-1 negative expression(P<0.05).MAGEA4 positive expression,lymph node metastasis,TNM stage IIIA and NY-ESO-1 positive expression were risk factors for poor prognosis of NSCLC patients(P<0.05).Conclusion:The positive expression rates of MAGEA4 and NY-ESO-1 in NSCLC tissues are increase,which are relate to lymph node metastasis,TNM stage IIIA,poor differentiationand poor prognosis of NSCLC patients.

关 键 词：非小细胞肺癌 黑素瘤相关抗原A4 纽约食管鳞状上皮癌抗原1 病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]