磁共振动态增强扫描联合血清SCCA、TSGF、HE4对早期宫颈癌淋巴结转移的预测价值  

Predictive Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined with Serum SCCA,TSGF and HE4 in Lymph Node Metastasis of Early Cervical Cancer

作　　者：王燕[1] 李亚萍[1] 王晓娟[1] 高婉 郗新娟 姜雪勤 WANG Yan;LI Ya-ping;WANG Xiao-juan;GAO Wan;XI Xin-juan;JIANG Xue-qin(Department of Obstetrics,Xi'an Central Hospital,Xi'an,Shaanxi,710003,China;Department of Imaging,Weinan First Hospital of Shaanxi,Weinan,Shaanxi,714000,China;Department of Gynaecology and Obstetrics,Genertec Universal Xi'an Bei Huan Hospital,Xi'an,Shaanxi,710032,China)

机构地区：[1]西安市中心医院妇产科,陕西西安710003 [2]陕西省渭南市第一医院影像科,陕西渭南714000 [3]通用环球西安北环医院妇产科,陕西西安710032

出　　处：《现代生物医学进展》2024年第22期4345-4347,共3页Progress in Modern Biomedicine

基　　金：陕西省卫生健康委科研基金项目(2021D006)。

摘　　要：目的:探讨磁共振动态增强扫描(DCE-MRI)联合血清鳞状细胞癌抗原(SCCA)、肿瘤特异性生长因子(TSGF)、附睾蛋白4(HE4)对早期宫颈癌淋巴结转移(LNM)的预测价值。方法:根据112例早期宫颈癌患者术后病理检查结果将其分为LNM组(27例)和非LNM组(85例)。比较两组一般资料、DCE-MRI定量参数[速率常数(K_(ep))、容量转移常数(K^(trans))、血管外细胞外容积分数(Ve)]、血清SCCA、TSGF、HE4水平。受试者工作特征(ROC)曲线分析DCE-MRI定量参数联合血清SCCA、TSGF、HE4对早期宫颈癌患者发生LNM的预测价值。结果:LNM组国际妇产科联盟(FIGO)分期IIA1~IIA2期比例、血清SCCA、TSGF、HE4水平、K_(ep)、K^(trans)均高于非LNM组(P<0.05),两组Ve比较无差异(P>0.05)。K_(ep)、K^(trans)、血清SCCA、TSGF、HE4单独及联合预测早期宫颈癌患者发生LNM具有较高的敏感度、特异度,联合检验预测早期宫颈癌患者发生LNM的曲线下面积(AUC)高于各指标单独检验。结论:DCE-MRI定量参数联合血清SCCA、TSGF、HE4对早期宫颈癌患者发生LNM具有较高的预测价值,可用于早期宫颈癌LNM的辅助预测。Objective:To investigate the predictive value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with serum squamous cell carcinoma antigen(SCCA),tumor specific growth factor(TSGF)and epididymis protein 4(HE4)in lymph node metastasis(LNM)of early cervical cancer.Methods:112 patients with early cervical cancer were divided into LNM group(27 cases)and non LNM group(85 cases)according to the results of postoperative pathological examination.The general data,DCE-MRI quantitative parameters[rate constant(K_(ep)),volume transfer constant(K^(trans)),extravascular extracellular volume fraction(Ve)],serum SCCA,TSGF and HE4 levels were compared between two groups.The predictive value of DCE-MRI quantitative parameters combined with serum SCCA,TSGF and HE4 for LNMin patients with early cervical cancer were analyzed by receiver operating characteristic(ROC)curve.Results:The proportion of international federation of gynecology and obstetrics(FIGO)stage IIA1~IIA2,levels of serum SCCA,TSGF,HE4,K_(ep) and K^(trans) in LNM group were higher than that in non LNM group(P<0.05).There was no significant difference in Ve between two groups(P>0.05).K_(ep),K^(trans),serum SCCA,TSGF,HE4 alone and in combination had high sensitivity and specificity in predicting LNM in patients with early cervical cancer,the area under the curve(AUC)of combined test in predicting LNM in patients with early cervical cancer was higher than that of each index alone.Conclusion:DCE-MRI quantitative parameters combined with serum SCCA,TSGF and HE4 have high predictive value for LNM in patients with early cervical cancer,and can be used for auxiliary prediction of LNM in early cervical cancer.

关 键 词：磁共振动态增强扫描 SCCA TSGF HE4 宫颈癌 淋巴结转移 预测价值 

分 类 号：R737.33[医药卫生—肿瘤]