丙戊酸镁联合维生素B12及叶酸治疗癫痫的效果  

Effect of Magnesium Valproate Combined with Vitamin B12 and Folic Acid in the Treatment of Epilepsy

作　　者：何玉清 代全德[2] HE Yuging;DAl Quande(Deparment oflnteral Medieine,the Seeond People's Hospital ofyucheng County,shanggiu 476334,China;Department of Neurology,Shangqiu First People's Hospital,Shangqiu 476100,China)

机构地区：[1]商丘市虞城县第二人民医院内科,河南商丘476334 [2]商丘市第一人民医院神经内科,河南商丘476100

出　　处：《临床医学工程》2024年第12期1511-1512,共2页Clinical Medicine & Engineering

摘　　要：目的观察丙戊酸镁联合维生素B12、叶酸治疗癫痫的效果及安全性。方法131例癫痫患者随机分为两组。对照组采用丙戊酸镁治疗,观察组在对照组基础上采用维生素B12、叶酸治疗。比较两组的治疗效果、血清指标、不良反应及复发率。结果观察组的总有效率为96.67%,高于对照组的84.62%(P<0.05)。治疗后,两组的Hcy、血氨水平均升高,但观察组低于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。观察组的复发率为1.52%,低于对照组的10.77%(P<0.05)。结论丙戊酸镁联合维生素B12及叶酸治疗癫痫的近期及远期效果较好,可降低Hcy及血氨水平,安全性尚可。Objective To observe the effect and safety of magnesium valproate combined with vitamin B12 and folic acid in the treatment of epilepsy.Methods 131 patients with epilepsy were randomly divided into two groups.The control group was treated with magnesium valproate,and the observation group was treated with vitamin B12 and folic acid on the basis of the control group.The therapeutic effect,serum indicators,adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate in the observation group was 96.67%,higher than 84.62%in the control group(P<0.05).After treatment,the levels of Hcy and blood ammonia in the two groups increased,but those in the observation group were lower than those in the control group(P<0.05).No significant difference was found in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate in the observation group was 1.52%,lower than 10.77%in the control group(P<0.05).Conclusions Magnesium valproate combined with vitamin B12 and folic acid has good short-term and long-term effects in the treatment of epilepsy,which can reduce Hcy and blood ammonia levels,with acceptable safety.

关 键 词：丙戊酸镁 维生素B12 叶酸 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]