PD-1 and LAG-3:synergistic fostering of T cell exhaustion  

作　　者：Maike Hofmann Robert Thimme Wolfgang W.Schamel 

机构地区：[1]Department of Medicine II,Medical Center,Faculty of Medicine,University of Freiburg,Freiburg,Germany [2]Signaling Research Centers BIOSS and CIBSS,University of Freiburg,Freiburg,Germany [3]Department of Immunology,Faculty of Biology,University of Freiburg,Freiburg,Germany [4]Centre for Chronic Immunodeficiency(CCI),Faculty of Medicine,University of Freiburg,Freiburg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第11期4779-4780,共2页信号转导与靶向治疗（英文）

基　　金：supported by the DFG under Germany’s Excellence Strategy-EXC-2189-Project ID:390939984;under the Excellence Initiative of the German Federal and State Governments-EXC-294;in part by the Ministry for Science,Research and Arts of the State of Baden-Württemberg;Further support is given by the German Research Foundation(DFG)under FOR2799(SCHA976/8-2 to W.W.S.);CRC1381(Project ID:403222702-A9 to W.W.S.);CRC1160(Project ID:256073931-A02 to R.T.and M.H.);TRR179(Project ID:272983813-TP01 to R.T.and TP20 to M.H.);CRC1479(Project ID:441891347-P10 to M.H.);M.H.is supported by the Heisenberg program of the German Research Foundation.

摘　　要：In the August issue of Cell 2024,three back-to-back papers disentangled non-redundant inhibitory mechanisms of PD-1 and LAG-3 in exhausted murine and human CD8+T cells.^(1-3) These findings will have a clear impact on checkpoint blockade therapies against a variety of tumors.

关 键 词：SYNERGISTIC REDUNDANT finding 

分 类 号：R392[医药卫生—免疫学]