Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis  

作　　者：Ran Liu Zixuan Luo Chong Dai Yuchen Wei Shuqing Yan Xinwen Kuang Kuan Qi Aisi Fu Yinxin Li Shuai Fu Zhengning Ma Wen Dai Xiao Xiao Qing Wu Haokui Zhou Yan Rao Jingping Yuan Ting Shi Zixin Deng Chuang Chen Tiangang Liu 

机构地区：[1]Renmin Hospital of Wuhan University,Wuhan University,430071 Wuhan,China [2]State Key Laboratory of Microbial Metabolism,Joint International Research Laboratory of Metabolic&Developmental Sciences,and School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,200240 Shanghai,China [3]CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,518055 Shenzhen,China [4]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education and School of Pharmaceutical Sciences,Wuhan University,430072 Wuhan,China [5]Department of Microbiology,The Chinese University of Hong Kong,Hong Kong,China [6]Zhongnan Hospital of Wuhan University,Wuhan University,430071 Wuhan,China [7]Dgensee Co.,Ltd,430073 Wuhan,China [8]Hesheng Tech,Co.,Ltd,430073 Wuhan,China [9]Animal Biosafety Level III Laboratory at the Center for Animal Experiment,Wuhan University School of Medicine,Wuhan University,430071 Wuhan,China [10]TaiKang Center for Life and Medical Sciences,Wuhan University,430072 Wuhan,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第11期5250-5266,共17页信号转导与靶向治疗（英文）

基　　金：supported by the National Key Research and Development Program of China(2018YFA0900400 to T.L.);Leading Talents of the Ten Thousand Talents Program to T.L.,Young Elite Scientists Sponsorship Program by China Association for Science and Technology to R.L.,the Shenzhen Institute of Synthetic Biology Scientific Research Program(Z.X.and R.L.);funding from State Key Laboratory of Microbial Metabolism,Shanghai Jiao Tong University(MMLZD24-01);the grants from The Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCFZ-2022-015)to C.C.;the Fundamental Research Funds for the Central Universities(2042019kf0229)to C.C.;the Natural Science Foundation of Hubei Province(2023AFB701)to C.C.

摘　　要：Granulomatous lobular mastitis(GLM)is a chronic idiopathic granulomatous mastitis of the mammary gland characterized by significant pain and a high propensity for recurrence,the incidence rate has gradually increased,and has become a serious breast disease that should not be ignored.GLM is highly suspected relative to microbial infections,especially those of Corynebacterium species;however,the mechanisms involved are unclear,and prevention and treatment are difficult.In this study,we demonstrated the pathogenicity of Corynebacterium parakroppenstedtii in GLM using Koch’s postulates.Based on the drug sensitization results of C.parakroppenstedtii,and utilizing a retrospective study in conjunction with a comprehensive literature review,we suggested an efficacious,targeted antibiotic treatment strategy for GLM.Subsequently,we identified the pathogenic factor as a new type of glycolipid(named corynekropbactins)secreted by C.parakroppenstedtii.Corynekropbactins may chelate iron,cause the death of mammary cells and other mammary-gland-colonizing bacteria,and increase the levels of inflammatory cytokines.We further analyzed the prevalence of C.parakroppenstedtii infection in patients with GLM.Finally,we suggested that the lipophilicity of C.parakroppenstedtii may be associated with its infection route and proposed a possible model for the development of GLM.This research holds significant implications for the clinical diagnosis and therapeutic management of GLM,offering new insights into targeted treatment approaches.

关 键 词：PREVENTION DIAGNOSIS TREATMENT 

分 类 号：R655.8[医药卫生—外科学]