Next-generation aluminum adjuvants:Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line drugs  

作　　者：Zhenwei Su Hamz oucetta Jiahui Shao Jinling Huang Ran Wang Aining Shen Wei He Zhi Ping Xu Lingxiao Zhang 

机构地区：[1]Institute of Systems and Physical Biology,Shenzhen Bay Laboratory,Shenzhen 518107,China [2]School of Medicine,Hangzhou City University,Hangzhou 310015,China [3]School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China [4]Interdisciplinary Nanoscience Center(INANO),Aarhus University,Aarhus 8000,Denmark

出　　处：《Acta Pharmaceutica Sinica B》2024年第11期4665-4682,共18页药学学报（英文版）

基　　金：European Union's Research and Innovation Program under the Marie Skłodowska-Curie grant agreement(No.101064861);National Natural Science Foundation of China(Nos.32101123,82073782 and 82241002);Guangdong Basic and Applied Basic Research Foundation(No.2022A1515110109,China);Natural Science Foundation of Ningbo(No.2022J273,China).

摘　　要：Aluminum adjuvants(Alum),approved by the US Food and Drug Administration,have been extensively used in vaccines containing recombinant antigens,subunits of pathogens,or toxins for almost a century.While Alums typically elicit strong humoral immune responses,their ability to induce cellular and mucosal immunity is limited.As an alternative,layered double hydroxide(LDH),a widely used antacid,has emerged as a novel class of potent nano-aluminum adjuvants(NanoAlum),demonstrating advantageous physicochemical properties,biocompatibility and adjuvanticity in both humoral and cellular immune responses.In this review,we summarize and compare the advantages and disadvantages of Alum and NanoAlum in these properties and their performance as adjuvants.Moreover,we propose the key features for ideal adjuvants and demonstrate that LDH NanoAlum is a promising candidate by sum-marizing its current progress in immunotherapeutic cancer treatments.Finally,we conclude the review by offering our integrated perspectives about the remaining challenges and future directions for NanoAlum's application in preclinical/clinical settings.

关 键 词：Aluminum adjuvants Layered double hydroxide Nano-aluminum adjuvants Cancer immunotherapy T cell immunity IMMUNOMODULATORY Immunogenic cell death Metal cations 

分 类 号：R96[医药卫生—药理学]