Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy  

作　　者：Hongyan Zhang Yujie Li Jingyi Huang Limei Shen Yang Xiong 

机构地区：[1]School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [2]Academy of Chinese Medical Science,Zhejiang Chinese Medical University,Hangzhou 310053,China [3]Division of Molecular Pharmaceutics,Eshelman School of Pharmacy,University of North Carolina at Chapel Hill,NC 27599,USA

出　　处：《Acta Pharmaceutica Sinica B》2024年第11期4717-4737,共21页药学学报（英文版）

基　　金：National Natural Science Foundation of China(82174095,China);Natural Science Foundation of Zhejiang Province(LZ22H290001,China);Zhejiang Province Traditional Chinese Medicine Science and Technology Project(2023ZL362,China).

摘　　要：Over the past decade,research has increasingly identified unique dysregulations in lipid metabolism within the tumor microenvironment(TME).Lipids,diverse biomolecules,not only constitute biological membranes but also function as signaling molecules and energy sources.Enhanced synthesis or uptake of lipids in the TME significantly promotes tumorigenesis and proliferation.Moreover,lipids secreted into the TME influence tumor-resident immune cells(TRICs),thereby aiding tumor survival against chemotherapy and immunotherapy.This review aims to highlight recent advancements in under-standing lipid metabolism in both tumor cells and TRICs,with a particular emphasis on exogenous lipid uptake and endogenous lipid de novo synthesis.Targeting lipid metabolism for intervention in anticancer therapies offers a promising therapeutic avenue for cancer treatment.Nano-drug delivery systems(NDDSs)have emerged as a means to maximize anti-tumor effects by rewiring tumor metabolism.This review provides a comprehensive overview of recent literature on the development of NDDSs targeting tumor lipid metabolism,particularly in the context of tumor immunotherapy.It covers four key aspects:reprogramming lipid uptake,reprogramming lipolysis,reshaping fatty acid oxidation(FAO),and reshuf-fing lipid composition on the cell membrane.The review concludes with a discussion of future prospects and challenges in this burgeoning field of research.

关 键 词：Lipid signaling Cancerprogression Lipid metabolic reprogramming IMMUNERESPONSE Precisiontargeting Nano-based drugdelivery systems Antitumortherapy Clinical treatment 

分 类 号：R730.51[医药卫生—肿瘤]