Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses  

作　　者：Conghao Zhong Xiaochang Li Dailu Guan The ChickenGTEx Consortium Boxuan Zhang Xiqiong Wang Liang Qu Huaijun Zhou Lingzhao Fang Congjiao Sun Ning Yang 

机构地区：[1]State Key Laboratory of Animal Biotech Breeding and Frontier Science Center for Molecular Design Breeding,China Agricultural University,Beijing 100193,China [2]Department of Animal Science,University of California,Davis,CA 95616,USA [3]Jiangsu Institute of Poultry Science,Yangzhou,Jiangsu 225125,China [4]Center for Quantitative Genetics and Genomics(QGG),Aarhus University,Aarhus 8000,Denmark [5]不详

出　　处：《Journal of Genetics and Genomics》2024年第12期1423-1434,共12页遗传学报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFF1000204 and 2021YFD1300600);STI 2030-Major Projects(2023ZD04052);the Open Projects of Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province(JQLAB-KF-202301);China Agriculture Research Systems(CARS-40);the 2115 Talent Development Program of China Agricultural University。

摘　　要：Chicken body weight(BW)is a critical trait in breeding.Although genetic variants associated with BW have been investigated by genome-wide association studies(GWAS),the contributions of causal variants and their molecular mechanisms remain largely unclear in chickens.In this study,we construct a comprehensive genetic atlas of chicken BW by integrative analysis of 30 age points and 5 quantitative trait loci(QTL)across 27 tissues.We find that chicken growth is a cumulative non-linear process,which can be divided into three distinct stages.Our GWAS analysis reveals that BW-related genetic variations show ordered patterns in these three stages.Genetic variations in chromosome 1 may regulate the overall growth process,likely by modulating the hypothalamus-specific expression of SLC25A30 and retina-specific expression of NEK3.Moreover,genetic variations in chromosome 4 and chromosome 27 may play dominant roles in regulating BW during Stage 2(8-22 weeks)and Stage 3(23-72 weeks),respectively.In summary,our study presents a comprehensive genetic atlas regulating developmental stage-specific changes in chicken BW,thus providing important resources for genomic selection in breeding programs.

关 键 词：CHICKEN Body weight AGE-DEPENDENT Molecular quantitative loci GWAS FarmGTEx 

分 类 号：S831.2[农业科学—畜牧学]