AGE-DEPENDENT

作品数：113被引量：207H指数：8
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相关机构：上海交通大学复旦大学上海医科大学附属中山医院中国科学院上海生命科学研究院更多>>
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Age-dependent alpha-synuclein aggregation and Lewy body formation in Parkinson's disease
《Neural Regeneration Research》2025年第12期3533-3534,共2页Chun Chau Sung Kenny K.K.Chung 
supported by the Innovation and Technology Commission (ITCPD/17-9);the Hong Kong Research Grants Council,China (GRF16104517)(to KKKC)。
Parkinson's disease (PD) is a common degenerative disorder that is becoming increasingly prevalent because of the global aging population.The exact cause of the disorder is unknown;however,recent studies have suggeste...
关键词：PATHOGENESIS AGGREGATION BECOMING 
A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis
《Neural Regeneration Research》2025年第7期2029-2037,共9页Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu 
supported by University of Macao,China,Nos.MYRG2022-00054-FHS and MYRG-GRG2023-00038-FHS-UMDF(to ZY);the Macao Science and Technology Development Fund,China,Nos.FDCT0048/2021/AGJ and FDCT0020/2019/AMJ and FDCT 0011/2018/A1(to ZY);Natural Science Foundation of Guangdong Province of China,No.EF017/FHS-YZ/2021/GDSTC(to ZY)。
To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral cortex.However,these me...
关键词：AGE-DEPENDENT cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy PHOTOTHROMBOSIS vascular imaging 
Age-dependent genetic architectures of chicken body weight explored by multidimensional GWAS and molQTL analyses
《Journal of Genetics and Genomics》2024年第12期1423-1434,共12页Conghao Zhong Xiaochang Li Dailu Guan The ChickenGTEx Consortium Boxuan Zhang Xiqiong Wang Liang Qu Huaijun Zhou Lingzhao Fang Congjiao Sun Ning Yang 
supported by the National Key Research and Development Program of China(2022YFF1000204 and 2021YFD1300600);STI 2030-Major Projects(2023ZD04052);the Open Projects of Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province(JQLAB-KF-202301);China Agriculture Research Systems(CARS-40);the 2115 Talent Development Program of China Agricultural University。
Chicken body weight(BW)is a critical trait in breeding.Although genetic variants associated with BW have been investigated by genome-wide association studies(GWAS),the contributions of causal variants and their molecu...
关键词：CHICKEN Body weight AGE-DEPENDENT Molecular quantitative loci GWAS FarmGTEx 
Maize multi-omics reveal leaf water status controlling of differential transcriptomes,proteomes and hormones as mechanisms of age-dependent osmotic stress response in leaves
《Stress Biology》2024年第1期525-542,共18页Liangjie Niu Wenkang Wang Yingxue Li Xiaolin Wu Wei Wang 
supported by the National Natural Science Foundation of China(32272026 and U1904107 to W.W.);the National Key Laboratory of Wheat and Maize Crop Science,Henan agricultural University,China(39990101 to W.W.).
Drought-induced osmotic stress severely affects the growth and yield of maize.However,the mechanisms underlying the different responses of young and old maize leaves to osmotic stress remain unclear.To gain a systemat...
关键词：Age-related changes Old and young leaves Osmotic stress PHYTOHORMONE Proteome Transcriptome Zea mays 
THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation
《Acta Pharmacologica Sinica》2024年第10期2107-2118,共12页Heng-hui Xu Sheng-xin Hao He-yang Sun Xin-xin Dong Yuan Lin Han Lou Li-min Zhao Ping-ping Tang Zi-jia Dou Jing-jing Han Meng-han Du Zhou-xiu Chen Philipp Kopylov Dmitry Shchekochikhin Xin Liu Yong Zhang 
supported by the National Natural Science Foundation of China(82273919,82270396);the HMU Marshal Initiative Funding(HMUMIF-21022);the Science Foundation for the Excellent Youth Scholars of Heilongjiang Province(JJ2023YX0509).
Diabetic cardiomyopathy(DCM)is a complication of diabetes mellitus characterized by heart failure and cardiac remodeling.Previous studies show that tetrahydroberberrubine(THBru)retrogrades cardiac aging by promoting P...
关键词：diabetic cardiomyopathy tetrahydroberberrubine RAGE INFLAMMATION 
Voltage-dependent P-Q Reserve Capacity Evaluation for TSO-DSO Interface Considering Uncertainties of DGs and FLs被引量：1
《CSEE Journal of Power and Energy Systems》2024年第5期1935-1954,共20页Yeyan Xu Liangzhong Yao Tianjiao Pu Siyang Liao Fan Cheng Ye Li Xinying Wang 
supported by the National Key R&D Program of China(2020YFB0905900);Science and Technology Project of SGCC(State Grid Corporation of China):The key Technologies for Electric Internet of Things(SGTJDK00DWJS2100042).
Increasing distributed generators(DGs)and flexible loads(FLs)enable distribution systems to provide both active and reactive power reserves(P-Q reserves)in supporting the frequency and voltage regulations of transmiss...
关键词：Generalized robust chance-constrained optimization reserve capacity evaluation sliding mode control transmission-distribution system coordination voltage-dependent P-Q reserve capacity 
The intrinsic developmental age signal defines an age-dependent climbing behavior in cucumber
《Horticultural Plant Journal》2024年第3期797-808,共12页Zezhou Hong Xinrui Wang Zipei Fan Jiahao Wang Aiyi Yang Guochao Yan Yong He Huasen Wang Zhujun Zhu Yunmin Xu 
supported by the Natural Science Foundation of Zhejiang province(Grant Nos.LZ20C150001,LY21C150002);National Natural Science Foundation of China(Grant No.32202583).
The tendril is a climbing organ in cucurbits and functions in physical support and to avoid shading by neighboring vegetation.However,how cucurbits produce tendrils to obtain climbing ability is largely unknown.In thi...
关键词：CUCUMBER TENDRIL Age CsmiR156 CsSPL Climbing ability 
Differential leaf flooding resilience in Arabidopsis thaliana is controlled by ethylene signalingactivated and age-dependent phosphorylation of ORESARA1被引量：1
《Plant Communications》2024年第6期73-88,共16页Tom Rankenberg Hans van Veen Mastoureh Sedaghatmehr Che-Yang Liao Muthanna Biddanda Devaiah Evelien AStouten Salma Balazadeh Rashmi Sasidharan 
supported by the Netherlands Organization for Scientific Research grant 016.VIDI.171.006 to T.R.
The phytohormone ethylene is a major regulator of plant adaptive responses to flooding.In flooded plant tissues,ethylene quickly increases to high concentrations owing to its low solubility and diffusion rates in wate...
关键词：FLOODING abiotic stress HYPOXIA SENESCENCE ethylene 
Reactive oxygen species(ROS)-mediated M1 macrophage-dependent nanomedicine remodels inflammatory microenvironment for osteoarthritis recession被引量：2
《Bioactive Materials》2024年第3期545-561,共17页Chunchun Xue Jia Tian Zepeng Cui Yang Liu Dawei Sun Mengting Xiong Nanxing Yi Kaiqiang Wang Xiaofeng Li Yongjun Wang Hao Xu Weian Zhang Qianqian Liang 
supported by the following grants:National Natural Science Foundation(no.81920108032,81873321,81930116,81973881,81804122 and 52333014);State Administration of Traditional Chinese Medicine-Young Qhuang Scholar,New interdisciplinary research Project of Shanghai Municipal Health Commission(no.2022JC005);Traditional Chinese Medicine Research Project Innovation Team Project of Shanghai Health Commission(no.2022CX001);Shanghai"Science and Technology Innovation Action Plan"medical innovation research project(no.21Y11921400);Shanghai Top Priority Research Center Construction Project(no.2022ZZ01009);Shanghai University of TCM Xinglin Scholars Project(no.TCM[2020]23);Shanghai University of TCM Excellent Talents Training Program(no.TCM[2020]10).
Osteoarthritis(OA)is a common chronic inflammatory disorder.Effective remodeling of inflammatory microenvironment in the joint is a promising strategy to prevent OA.However,current drugs remain unsatisfactory due to a...
关键词：Reactive oxygen species OSTEOARTHRITIS Inflammatory microenvironment Macrophages polarization Apoptosis 
Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration
《Neural Regeneration Research》2023年第12期2667-2668,共2页Jacob Hudobenko Manoshi Gayen Marc RBenoit Neeraj Singh Riqiang Yan 
grants RF1AG058261, AG025493, NS074256, and AG046929 from the National Institutes of Health (to RY);the Cure Alzheimer’s Fund。
Owing to the increasing life expectancy, the prevalence of age-dependent neurodegenerative diseases will exert an enormous toll on our aging population, their caregivers and the healthcare system. It is anticipated th...
关键词：diseases ALZHEIMER PREVALENCE 
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