Multi-omics in nanoplastic research:a spotlight on aquatic life  

作　　者：Mohamed Helal Min Liu Honghong Chen Mingliang Fang Wenhui Qiu Frank Kjeldsen Knut Erik Tollefsen Vengatesen Thiyagarajan Henrik Holbech Elvis Genbo Xu 

机构地区：[1]Department of Biology,University of Southern Denmark,Odense 5230,Denmark [2]National Institute of Oceanography and Fisheries(NIOF),Cairo 11865,Egypt [3]School of Civil and Environmental Engineering,Nanyang Technological University,Singapore 639798,Singapore [4]Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen 518055,China [5]Eastern Institute for Advanced Study,Eastern Institute of Technology,Ningbo 315200,China [6]School of Environmental Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [7]Department of Environmental Science and Engineering,Fudan University,Shanghai 200433,China [8]Department of Biochemistry and Molecular Biology,University of Southern Denmark,Odense M 5230,Denmark [9]Norwegian Institute for Water Research(NIVA),Oslo N-0579,Norway [10]Norwegian University of Life Sciences(NMBU),Ås N-1432,Norway [11]The Swire Institute of Marine Sciences,School of Biological Sciences,The University of Hong Kong,Hong Kong 999077,China

出　　处：《Frontiers of Environmental Science & Engineering》2024年第11期21-38,共18页环境科学与工程前沿（英文）

基　　金：funded by the Sapere Aude Research Leader program from the Danish Council for Independent Research(No.0165-00056B);supported by the Research Council of Norway(No.315969);“In silico and experimental screening platform for characterizing the environmental impact of industry development in the Arctic(EXPECT)and NIVA’s Computational Toxicology Program(NCTP;Research Council Project No.342628).

摘　　要：Amidst increasing concerns about plastic pollution’s impacts on ecology and health,nanoplastics are gaining global recognition as emerging environmental hazards.This review aimed to examine the complex molecular consequences and underlying fundamental toxicity mechanisms reported from the exposure of diverse aquatic organisms to nanoplastics.Through the comprehensive examination of transcriptomics,proteomics,and metabolomics studies,we explored the intricate toxicodynamics of nanoplastics in aquatic species.The review raised essential questions about the consistency of findings across different omics approaches,the value of combining these omics tools to understand better and predict ecotoxicity,and the potential differences in molecular responses between species.By amalgamating insights from 37 omics studies(transcriptome 22,proteome six,and metabolome nine)published from 2013 to 2023,the review uncovered both shared and distinct toxic effects and mechanisms in which nanoplastics can affect aquatic life,and recommendations were provided for advancing omics-based research on nanoplastic pollution.This comprehensive review illuminates the nuanced connections between nanoplastic exposure and aquatic ecosystems,offering crucial insights into the complex mechanisms that may drive toxicity in aquatic environments.

关 键 词：ECOTOXICITY TRANSCRIPTOMICS Metabolomics PROTEOMICS Plastic pollution Toxicity mechanisms 

分 类 号：X505[环境科学与工程—环境工程] X171.5