基于数据挖掘探讨《景岳全书·痢疾》用药规律  

Disquisition the medication rule of treating dysentery in Jingyue Quanshu based on data mining

作　　者：管晓 梁菲 梁馨允 温文健 毕若娴 黄贵华[2] GUAN Xiao

机构地区：[1]广西中医药大学研究生院,广西南宁530000 [2]广西中医药大学第一附属医院,广西南宁530000

出　　处：《中医临床研究》2024年第32期118-122,共5页Clinical Journal Of Chinese Medicine

基　　金：黄贵华桂派中医大师传承工作室(桂中医药科教发[2024]1号);黄贵华广西名中医传承工作室项目(桂卫中医发[2017]2号);黄贵华桂派中医大师培养项目(桂中医药科教发[2022]6号);国医大师黄瑾明学术思想与临床诊疗传承发展研究中心建设项目(桂中医大党[2022]24号);广西研究生教育创新计划项目(YCBZ2023148)。

摘　　要：目的:挖掘《景岳全书》中张介宾(号景岳)治疗痢疾的方剂,分析总结其用药规律,为临床治疗溃疡性结肠炎等疾病提供参考。方法:纳入《景岳全书》所载治疗痢疾处方,建立数据库,进行药物频次、四气五味、归经与功效频次统计,以及关联规则分析及聚类分析,挖掘用药规律与经验。结果:共纳入76首方剂,涉及中药119味,累计频次473次,以甘草、白术、干姜、白芍、人参、附子、当归、熟地黄等32味药为高频中药,其药性多温,药味以甘、苦、辛为主,主要入脾经、胃经、肺经、心经、肾经。通过关联规则分析得到白术与人参、白术与茯苓、白芍与当归等15对核心药组;聚类分析可得到4类药物组合,类1:厚朴、干姜、附子、陈皮、木香、甘草;类2:干姜、吴茱萸、附子、熟地黄、木香、炙甘草;类3:黄连、黄芩、甘草、白芍、当归、木香、肉桂;类四:人参、白术、茯苓、炙甘草。所用药物多有补益、温阳、燥湿、理气之功。结论:本研究通过对《景岳全书》中治疗痢疾的76首方剂进行分析,发现张介宾治疗痢疾立足于本虚,以补益脾肾为主,温补阳气为要,亦不忽视滋补真阴,兼顾气血阴阳,以调和气血为重,用药精简且不拘泥于某一类,从外感湿热、内伤脾胃等角度用药。Objective:To excavate the prescription of ZHANG Jiebin in the treatment of dysentery in Jingyue Quanshu(《景O岳全书》),analyze and summarize its medication rules,in order to provide reference for clinical treatment of ulcerative colitis and other related diseases.Methods:The prescriptions for the treatment of dysentery contained in Jingyue Quanshu were included,and a database was established.The used frequency,four properties,five flavors,meridian tropism,and efficacy classification of Chinese medicines,as well as association rule analysis and cluster analysis were carried out to explore the medication rules and experience.Results:A total of 76 prescriptions were included,involving 119 Chinese medicines,with a cumulative frequency of 473 times.Thirty-two Chinese medicines such as Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae),Ganjiang(Rhizoma Zingiberis),Baishao(Radix Paeoniae Alba),Renshen(Radix Ginseng),Fuzi(Radix Aconiti Lateralis Preparata),Danggui(Radix Angelicae Sinensis),Shudihuang(Radix Rehmanniae Preparata)were high-frequency Chinese medicines.Its medicinal properties are warm,and the taste was mainly sweet,bitter and pungent.It mainly enters the spleen,stomach,lung,heart and kidney meridians.Through association rule analysis,a total of 15 core drug groups such as Baizhu and Renshen,Baizhu and Fuling(Poria),Baishao and Danggui were obtained.Cluster analysis got 4 drug combinations,class 1:Houpo(Cortex Magnoliae Officinalis),Ganjiang,Fuzi,Chenpi(Pericarpium Citri Reticulatae),Muxiang(Radix Aucklandiae),Gancao.Class 2:Ganjiang,Wuzhuyu(Fructus Evodiae),Fuzi,Shudihuang,Muxiang,Zhigancao(Radix Glycyrrhizae Preparata).Class 4:Huanglian(Rhizoma Coptidis),Huangqin(Radix Scutellariae),Gancao,Baisha Danggui,Muxiang,Rougui(Cortex Cinnamomi).Class 4:Renshen,Baizhu,Fuling,Zhigancao.Most of the drugs used have the functions of tonifying,warming Yang(阳),drying dampness and regulating Qi(气).Conclusion:In this study,through the analysis of 76 prescriptions for the treatment of dysentery i

关 键 词：痢疾 《景岳全书》 用药规律 关联规则 

分 类 号：R22[医药卫生—中医基础理论]