血塞通胶囊辅助治疗脑梗死恢复期对神经功能、颈动脉斑块稳定性的影响  

Effect of Xuesaitong Capsules on Neurological Function and Carotid Plaque Stabilityin Recovery Period of Cerebral Infarction

作　　者：丁春娜 钱辉 景江 DING Chunna;QIAN Hui;JING Jiang(Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Department of Rehabilitation Medicine,Affiliated Hospital of Shaoxing University of Arts and Sciences,Shaoxing Zhejiang 312000,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]绍兴文理学院附属医院康复医学科,浙江绍兴312000

出　　处：《新中医》2024年第13期68-72,共5页New Chinese Medicine

摘　　要：目的:观察血塞通胶囊辅助治疗脑梗死恢复期的临床疗效。方法:回顾性分析100例脑梗死恢复期患者的病历资料,根据治疗方法的不同分为研究组与对照组各50例。对照组给予常规西药治疗,研究组在对照组基础上给予血塞通胶囊辅助治疗,2组均治疗3个月。比较2组临床疗效,并比较2组治疗前后中医证候评分、神经功能缺损程度(NIHSS)评分、颈动脉斑块稳定性及氧化应激指标。结果:治疗后,研究组总有效率92.00%,高于对照组76.00%(P<0.05)。治疗后,2组半身不遂、言语謇涩、口舌歪斜、偏身麻木、头晕头痛、肢体肿胀、面色晦暗、口唇发绀等中医证候评分均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组NIHSS评分均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组颈动脉内膜中层厚度(IMT)、血管阻力指数(RI)水平均降低(P<0.05),且研究组低于对照组(P<0.05)。治疗后,2组丙二醛(MDA)、8-羟基脱氧鸟苷酸(8-OHdG)水平均降低(P<0.05),且研究组低于对照组(P<0.05);2组超氧化物歧化酶(SOD)水平均升高(P<0.05),且研究组高于对照组(P<0.05)。结论:血塞通胶囊辅助治疗脑梗死恢复期疗效显著,有利于减轻患者临床症状,促进神经功能恢复及颈动脉斑块稳定性。Objective:To observe the clinical effect of Xuesaitong Capsules assisting recovery period of cerebral infarction.Methods:A total of 100 cases of patients with cerebral infarction in the recovery period,whose medical records were given retrospective analysis,were divided into the study group and the control group according to different treatment methods,with 50 cases in each group.The control group received routine western medicine treatment,and the study group received adjuvant treatment with Xuesaitong Capsules based on the treatment of the control group.Both groups were treated for three months.The traditional Chinese medicine syndrome scores,National Institutes of Health Stroke Scale(NIHSS)scores,carotid plaque stability,and oxidative stress indicators before and after treatment,and the clinical effects were compared between the two groups.Results:After treatment,the total clinical effective rate was 92.00%in the study group,higher than that of 76.00%in the control group(P<0.05).After treatment,thescores of traditional Chinese medicine syndromes such as hemiplegia,speech difficulties,tongue andmouth deviation,unilateral numbness,dizziness and headache,limb swelling,dark complexion,andcyanosis of the lips in the two groups were decreased(P<0.05),and the scores in the study group werelower than those in the control group(P<0.05).After treatment,the NIHSS scores in the two groups weredecreased(P<0.05),and the score in the study group was lower than that in the control group(P<0.05).After treatment,the levels of intima-media thickness(IMT)and vascular resistance index(RI)in the carotidarteries in the two groups were decreased(P<0.05),and the levels in the study group were lower thanthose in the control group(P<0.05).After treatment,the levels of malondialdehyde(MDA)and 8-hydroxydeoxyguanosine(8-OHdG)in the two groups were decreased(P<0.05),and the levels in the studygroup were lower than those in the control group(P<0.05).The levels of superoxide dismutase(SOD)in thetwo groups were increased(P<0.05),and the level

关 键 词：脑梗死 恢复期 血塞通胶囊 神经功能 颈动脉斑块 

分 类 号：R743.33[医药卫生—神经病学与精神病学]