益生菌联合美沙拉嗪治疗炎症性肠病的临床效果分析  

Analysis of Clinical Effect of Probiotics Combined with Mesalazine in Treatment of Inflammatory Bowel Disease

作　　者：李书敏[1] 董琴琴 Li Shumin;Dong Qinqin(Department of Gastroenterology,Binzhou Central Hospital,Binzhou 251700,Shandong Province,China)

机构地区：[1]滨州市中心医院消化内科,山东滨州251700

出　　处：《中国社区医师》2024年第36期17-19,共3页Chinese Community Doctors

摘　　要：目的:探讨益生菌联合美沙拉嗪治疗炎症性肠病(IBD)的临床效果。方法:选取滨州市中心医院2021年2月—2022年2月收治的82例IBD患者作为研究对象,以随机数字表法分成对照组和研究组,各41例。对照组给予美沙拉嗪治疗,研究组在对照组基础上联合益生菌治疗。比较两组治疗效果、胃肠激素水平及不良反应发生情况。结果:研究组治疗总有效率高于对照组(P=0.007)。治疗前,两组胃动素(MTL)、胃泌素(GAS)、血管活性肠肽(VIP)水平比较,差异无统计学意义(P>0.05);治疗后,两组MTL水平均高于治疗前,且研究组高于对照组(P<0.05);两组GAS、VIP水平均低于治疗前,且研究组低于对照组(P<0.05)。研究组不良反应总发生率高于对照组(P=0.034)。结论:益生菌联合美沙拉嗪治疗IBD的临床效果显著,能够改善胃肠道激素水平,降低不良反应发生率。Objective:To explore the clinical effect of probiotics combined with mesalazine in the treatment of inflammatory bowel disease(IBD).Methods:A total of 82 IBD patients who were admitted to Binzhou Central Hospital February 2021 to February 2022 were selected as the study subjects.They were divided into the study group and the control group by random number table method,with 41 cases in each group.The control group was treated with mesalazine,while the study group was treated with probiotics on the basis of control group.The clinical effect,gastrointestinal hormone levels,and adverse reactions in the two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the control group(P=0.007).Before treatment,there was no significant difference in the levels of motilin(MTL),gastrin(GAS)and vasoactive intestinal peptide(VIP)between the two groups(P>0.05).After treatment,the MTL levels in the two groups were higher than those before treatment,and the level in the study group was higher than that in the control group(P<0.05).The levels of GAS and VIP in the two groups were lower than those before treatment,and the levels in the study group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the study group was higher than that in the control group(P=0.034).Conclusion:The clinical effect of probiotics combined with mesalazine in the treatment of IBD is significant,which can improve the gastrointestinal hormone levels and reduce the incidence of adverse reactions.

关 键 词：炎症性肠病 美沙拉嗪 益生菌 胃肠激素 

分 类 号：R574[医药卫生—消化系统]