MDM2基因T309G多态性与前列腺癌发病风险相关性的Meta分析  

Association between MDM2 gene T309G polymorphism and prostate cancer susceptibility:a meta-analysis

作　　者：刘双苔 习舒 李飞[1] 谭晓琳 LIU Shuangtai;XI Shu;LI Fei;TAN Xiaolin(Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 437101,P.R.China;Administrative Office of President,Zhongnan Hospital of Wuhan University,Wuhan 437101,P.R.China)

机构地区：[1]武汉大学中南医院泌尿外科,武汉430071 [2]武汉大学中南医院院长办公室,武汉430071

出　　处：《中国循证医学杂志》2024年第12期1406-1410,共5页Chinese Journal of Evidence-based Medicine

基　　金：国家自然科学基金项目(编号:82373411)。

摘　　要：目的探讨鼠双微体基因2(murine double minute 2,MDM2)基因T309G多态性与前列腺癌发病风险的相关性。方法计算机检索PubMed、Embase、WanFang Data和CNKI数据库,搜集关于MDM2基因T309G多态性与前列腺癌发病风险相关性的病例-对照研究,检索时限均从建库至2023年5月1日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 14.0软件进行Meta分析。结果共纳入10个病例-对照研究,包括5781例前列腺癌患者和5477例健康对照个体。Meta分析结果显示:MDM2基因T309G多态性与前列腺癌发病风险无相关性[等位基因模型G vs.T:OR=0.89,95%CI(0.77,1.04),P=0.13;纯合子模型GG vs.TT:OR=0.86,95%CI(0.64,1.16),P=0.32;杂合子模型TG vs.TT:OR=1.04,95%CI(0.86,1.26),P=0.12;显性模型GG+TG vs.TT:OR=0.96,95%CI(0.89,1.04),P=0.36;隐性模型GG vs.TG+TT:OR=0.84,95%CI(0.63,1.14),P=0.27]。按照人种及对照来源进行亚组分析的结果与总体分析结果相似,敏感性分析结果显示结果较稳健。结论当前证据表明,MDM2基因T309G多态性与前列腺癌发病风险无相关性。受纳入研究数量和质量限制,上述结论尚需开展更多高质量研究予以验证。Objective To systematically review the relationship between T309G polymorphism of murine double minute 2(MDM2)gene and susceptibility of prostate cancer.Methods The PubMed,Embase,WanFang Data,CNKI databases were electronically searched to collect case-control studies related to the objectives from inception to May,2023.Two reviewers independently screened literature,extracted data and assessed the risk of bias of the included studies.Metaanalysis was then performed by using Stata 14.0 software.Results A total of 10 studies involving 5781 patients and 5477 healthy controls were included.The results of meta-analysis showed that the MDM2 gene T309G polymorphism was not associated with preeclampsia(allele model G vs.T:OR=0.89,95%CI 0.77 to 1.04,P=0.13;homozygote model GG vs.TT:OR=0.86,95%CI 0.64 to 1.16,P=0.32;heterozygote model TG vs.TT:OR=1.04,95%CI 0.86 to 1.26,P=0.12;dominant model GG+TG vs.TT:OR=0.96,95%CI 0.89 to 1.04,P=0.36;recessive model GG vs.TG+TT:OR=0.84,95%CI 0.63 to 1.14,P=0.27).The results of subgroup analysis based on ethnicity and source of control were similar to the overall results.Sensitivity analysis showed that the results were robust.Conclusion Current evidence shows that the MDM2 gene T309G polymorphism is not associated with prostate cancer susceptibility.Due to the limited quality and quantity of the included studies,more high quality studies are needed to verify the above conclusion.

关 键 词：鼠双微体基因2 前列腺癌 基因多态性 系统评价 META分析 

分 类 号：R737.25[医药卫生—肿瘤]