mRNA疫苗在胰腺癌治疗中的优势及应用  

Advantages and application of mRNA vaccines in treatment of pancreatic cancer

作　　者：胡小杰 刘宏[2] Hu Xiaojie;Liu Hong(The First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China;Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation Center,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一医院肝胆胰外科及肝脏移植中心,太原030001

出　　处：《肿瘤研究与临床》2024年第10期790-793,共4页Cancer Research and Clinic

摘　　要：胰腺癌的常规治疗易出现耐药性, 显示出个性化精准治疗的必要性。癌症疫苗因具有包括多靶向、低毒性和诱导持久的免疫记忆等多方面的优势, 已成为胰腺癌治疗有前途的替代品。现已经开发了多种针对胰腺癌的常规疫苗, 然而整体疗效仍不尽如人意。与常规疫苗相比, 基于mRNA的疫苗在个性化精确治疗方面提供了先进的技术和概念, 代表了胰腺癌有潜力的新型治疗方式。本文探讨了目前胰腺癌疫苗的研究进展, 强调了mRNA疫苗相对于常规疫苗的优越性, 并总结了设计和应用个性化mRNA疫苗精准治疗胰腺癌的可行性。Conventional treatment strategies for pancreatic cancer are often resistant,showing the need for personalized precision treatment.Cancer vaccines have emerged as a promising alternative to pancreatic cancer treatment because of their multiple advantages,including multitargeting,low toxicity and induction of long-lasting immune memory.Several conventional vaccines against pancreatic cancer have been developed.However,their overall efficacy is still unsatisfactory.Compared to the conventional vaccines,mRNA-based vaccines offer a technological and conceptual advance in personalized precision therapy and therefore represent a potential novel treatment option for pancreatic cancer.This review discusses the current research progress of pancreatic cancer vaccines,emphasizes the superiority of mRNA vaccines over conventional vaccines,and summarizes the feasibility of designing and applying personalized mRNA vaccines for precision treatment of pancreaticcancer.

关 键 词：胰腺肿瘤 mRNA疫苗 癌症疫苗 

分 类 号：R735.9[医药卫生—肿瘤] R730.51[医药卫生—临床医学]