循环肿瘤细胞在乳腺癌中的研究进展  

Progress of circulating tumor cells in breast cancer

作　　者：张永梅[1] 郭钢[2] 张华一 Zhang Yongmei;Guo Gang;Zhang Huayi(Department of Clinical Laboratory,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Department of Breast Thyroid Surgery,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院检验科,呼和浩特010050 [2]内蒙古医科大学附属医院乳腺甲状腺外科,呼和浩特010050

出　　处：《肿瘤研究与临床》2024年第10期797-800,共4页Cancer Research and Clinic

摘　　要：循环肿瘤细胞(CTC)是指从恶性肿瘤原发部位脱落的通过血管或淋巴系统进入血液循环的细胞,其形成是肿瘤转移过程的关键步骤。CTC能够在时间和空间上反映实体瘤的异质性,可以作为病理诊断、预后判读、疾病检测和分子分型判断的重要补充手段。一些研究者还利用CTC开展体外培养、功能检测及免疫组织化学分析等研究。文章就CTC在乳腺癌诊断、疗效、预后、转移评估应用中的近期研究进行综述。Circuating tumor cells(CTC)are cells that are shed from the primary sites of malignancies and enter the bloodstream through the blood vessel or lymphatic system.The formation of CTC is a key step in the tumor metastasis process.CTC can reflect the heterogeneity of solid tumors in time and space,and can be used as an important supplementary method for pathological diagnosis,prognostic interpretation,disease detection and molecular typing.Some researchers also apply CTC to carry out culture in vitro,functional detection and histochemical analysis.This article reviews the recent research of CTC in diagnosis and assessment of efficacy,prognosis and metastasis of breast cancer.

关 键 词：乳腺肿瘤 循环肿瘤细胞 肿瘤转移 

分 类 号：R737.9[医药卫生—肿瘤]