脉冲射频联合神经阻滞治疗对顽固性带状疱疹后神经痛患者SF-MPQ评分及血清P物质、IL-1β水平的影响  

Effect of pulsed radiofrequency combined with nerve block on SF-MPQ score,levels of serum substance P and IL-1βin patients with refractory postherpetic neuralgia

作　　者：李宝福 刘冰 王春满 李琳[1] 高谦[1] LI Baofu;LIU Bing;WANG Chunman;LI Lin;GAO Qian(Pain Department,Hengshui Municipal People's Hospital(Harrison International Peace Hospital),Hengshui,Hebei Province 053000,China)

机构地区：[1]衡水市人民医院(哈励逊国际和平医院)疼痛科,河北衡水053000

出　　处：《介入放射学杂志》2024年第11期1197-1202,共6页Journal of Interventional Radiology

基　　金：河北省卫生厅科研基金(2023174、20232176)。

摘　　要：目的探讨脉冲射频联合神经阻滞治疗对顽固性带状疱疹后神经痛(PHN)患者简式McGill疼痛问卷表(SF-MPQ)评分及血清P物质、白细胞介素(IL)-1β水平的影响。方法选取2021年4月至2022年4月衡水市人民医院收治的219例PHN患者为研究对象,根据随机数表法均分为A组(73例)、B组(73例)和C组(73例),A组PHN患者接受神经脉冲射频治疗,B组PHN患者接受神经阻滞治疗,C组PHN患者接受神经阻滞联合神经脉冲射频治疗,比较各组患者SF-MPQ评分、血清P物质、IL-1β水平、焦虑抑郁情况、生活质量变化情况。结果219例PHN患者中因失访、研究期间转为其他方式治疗脱落6例,最终A组入组71例、B组入组70例、C组入组72例。治疗后7 d(AT7)、30 d(AT30)和90 d(AT90)时,C组PHN患者SF-MPQ疼痛分级指数评定(PRI)评分、视觉模拟评分法(VAS)评分、现时疼痛强度评定(PPI)评分均低于A组、B组(P<0.05),血清P物质、IL-1β水平均低于A组、B组(P<0.05),健康问卷抑郁量表(PHQ9)评分、广泛性焦虑量表(DAG7)评分、综合评定问卷(GQOL-74)评分均低于A组、B组(P<0.05)。结论脉冲射频联合神经阻滞用于顽固性PHN治疗能有效降低患者疼痛和血清P物质、IL-1β水平,缓解患者的焦虑、抑郁情绪,提高生活质量。Objective To explore the effect of pulsed radiofrequency combined with nerve block on the score of short-form of McGill pain questionnaire(SF-MPQ)and the levels of serum substance P(SP)and interleukin(IL)-1βin patients with refractory postherpetic neuralgia(PHN).Methods A total of 219 patients with PHN,who were admitted to the Hengshui Municipal People′s Hospital of China between April 2021 and April 2022,were collected as the objects of study.Using random number table method,the patients were divided into group A(n=73,receiving pulsed radiofrequency therapy),group B(n=73,receiving nerve block therapy),and group C(n=73,receiving pulsed radiofrequency combined with nerve block therapy).The SF-MPQ score,levels of serum SP and IL-1β,degree of anxiety and depression,and quality of life were compared between each other among the three groups.Results Among the 219 patients with PHN,6 patients were excluded from this study due to losing in touch or due to receiving other therapies,and finally group A had 71 patients,group B had 70 patients,and group C had 72 patients.At 7 d after treatment(AT_7),30 d after treatment(AT_(30))and 90 d after treatment(AT_(90)),in group C the scores of pain rating index(PRI),visual analogue scale(VAS)and present pain intensity(PPI)were obviously lower than those in group A and group B(P<0.05),the levels of serum SP and IL-1βwere strikingly lower than those in group A and group B(P<0.05),and the scores of patient health questionnaire-9(PHQ9),generalized anxiety disorder 7-item(DAG7)and Generic Quality of Life Inventory 74(GQOL-74)were remarkably lower than those in group A and group B(P<0.05).Conclusion Pulsed radiofrequency combined with nerve block can effectively reduce the pain degree and the serum SP and IL-1βlevels,relieve the degree of anxiety and depression in patients with refractory PHN,which can improve the quality of life.

关 键 词：带状疱疹后神经痛 脉冲射频 神经阻滞 简式McGill疼痛问卷表 P物质 白细胞介素-6 生活质量 

分 类 号：R741.05[医药卫生—神经病学与精神病学]