孤立性肠系膜上动脉夹层腔内介入术后应用仿生唾液腺诱导技术缓解继发口干症的效果研究  

The clinical effect of biomimetic salivary gland induction technique in alleviating secondary xerostomia after endovascular intervention of isolated superior mesenteric artery dissection

作　　者：李燕[1] 葛静萍[1] 尹媛媛 孙红霞[1] LI Yan;GE Jingping;YIN Yuanyuan;SUN Hongxia(Department of Interventional and Vascular Surgery,Affiliated Nanjing Hospital of Nanjing Medical University(Nanjing Municipal First Hospital),Nanjing,Jiangsu Province 210001,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)介入血管科,江苏南京210001

出　　处：《介入放射学杂志》2024年第11期1229-1233,共5页Journal of Interventional Radiology

基　　金：国家自然科学基金(81871463);南京市卫生科技发展专项资金项目(ZKX23033);南京市第一医院星火培育计划。

摘　　要：目的探讨仿生唾液腺诱导技术在孤立性肠系膜上动脉夹层(isolated superior mesenteric artery dissection,ISMAD)介入术后缓解继发口干症的应用效果。方法随机数字抽样法选取2020年3月至2022年12月南京医科大学附属南京医院收治的ISMAD腔内治疗80例患者为研究对象。对照组40例患者术后1~48 h使用棉签蘸温水(25~35℃)湿润口唇,术后1~2 h内每15 min 1次,3~48 h内每30 min 1次。试验组40例患者术后1~48 h使用仿生唾液腺诱导技术提供15 mL/h的连续可控水流,持续保持口唇和口腔内湿润。观察两组术后1、12、24、48 h口干程度及口腔舒适度。结果试验组术后1、12、24、48 h口渴发生率及口渴程度显著低于对照组(P<0.01),试验组术后不同时间点口腔舒适度显著优于对照组(P<0.01)。结论ISMAD介入术后应用仿生唾液腺诱导湿润技术能显著降低口渴发生率,提高患者口腔舒适度。Objective To discuss the clinical effect of biomimetic salivary gland induction technology in alleviating secondary xerostomia after endovascular intervention of isolated superior mesenteric artery dissection(ISMAD).Methods Using random number sampling method,a total of 80 patients with ISMAD,who received endovascular intervention at the Affiliated Nanjing Hospital of Nanjing Medical University of China between March 2020 and December 2022,were selected as the research subjects.For the patients of control group(n=40)the warm-water(25-35℃)cotton swab was adopted to moisten the lips from one hour to 48 hours after endovascular intervention,which was given once every 15 minutes within postoperative 1-2 hours,which was followed by once every 30 minutes within postoperative 3-48 hours.For the patients of study group(n=40)with the help of biomimetic salivary gland induction technology a continuous and controlled water flow at a rate of 15 mL/h was given from one hour to 48 hours after endovascular intervention to continuously keep the lips and mouth moist.The postoperative one-,12-,24-and 48-hour degrees of mouth dryness and oral comfort in both groups were analyzed.Results The postoperative one-,12-,24-,and 48-hour incidence of thirsty and the degrees of severity in the study group were significantly lower than those in the control group(all P<0.01),and the degrees of oral comfort at postoperative different time points in the study group were remarkably better than those in the control group(all P<0.01).Conclusion The use of biomimetic salivary gland induction technology in patients with ISMAD after receiving endovascular intervention therapy can significantly reduce the incidence and severity of thirsty and improve oral comfort.

关 键 词：仿生唾液腺诱导 孤立性肠系膜上动脉夹层 介入术 口干症 

分 类 号：R574[医药卫生—消化系统]