Maresin-1调节免疫细胞在炎症性疾病中的作用研究进展  

Research progress on the role of immune cells regulated by Maresin-1 in inflammatory diseases

作　　者：刘苹[1] 祝光燕 夏海发[1] Liu Ping;Zhu Guangyan;Xia Haifa(Department of Anesthesiology,Institute of Anesthesia and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,the Key Laboratory of Anesthesiology and Resuscitation,Ministry of Education,Wuhan 430022,Hubei,China)

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,麻醉与危重病研究所,麻醉复苏教育部国家重点实验室,湖北武汉430022

出　　处：《中华危重病急救医学》2024年第10期1113-1116,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金(82272238);麻醉复苏教育部国家重点实验室开放基金项目(2023MZFS004)。

摘　　要：炎症反应是保护机体免受外界有害抗原和微生物侵害的宿主防御机制,炎症反应加剧会导致组织损伤并发展为全身炎症性疾病。Maresin-1作为具有代表性的ω-3脂肪酸衍生物,在急性炎症性疾病中对先天性免疫细胞(中性粒细胞和单核/巨噬细胞)具有调节作用,其促进感染性炎症消退的作用已被广泛探索。目前越来越多的证据表明,Maresin-1对适应性免疫系统也有直接作用,能防止急性炎症向慢性炎症过渡。本文通过分析近年来Maresin-1对炎症调控作用的相关文献,总结各种免疫细胞在炎症反应中的作用,以及Maresin-1对各类免疫细胞的调节机制,以期深入了解Maresin-1调节免疫细胞在炎症性疾病中的作用研究进展,从而为Maresin-1在炎症性疾病中作用的相关基础研究和临床应用提供理论基础。Inflammation reaction is a host defense mechanism that protects the host from harmful external antigens and microorganisms,and the intensification of inflammation reaction can lead to tissue damage and development of systemic inflammatory diseases.As a representative derivative ofω-3 fatty acids,Maresin-1 has been widely explored for its role in regulating innate immune cells(neutrophils and mononuclear/macrophages)and promoting the resolution of infectious inflammation in acute inflammatory diseases.There is now increasing evidence that Maresin-1 also has a direct effect on the adaptive immune system and prevents the transition from acute inflammation to chronic inflammation.By analyzing the literature related to the effect of Maresin-1 on the regulation of inflammation,this paper summarized the role of various immune cells in inflammatory response and the regulatory mechanism of Maresin-1 on various immune cells,so as to deeply understand the research progress of the role of Maresin-1 in regulating immune cells in inflammatory diseases.This study provides a theoretical basis for the basic research and clinical application of Maresin-1 in inflammatory diseases.

关 键 词：Maresin-1 免疫细胞 炎症性疾病 

分 类 号：R364.5[医药卫生—病理学]