Urchin-like piezoelectric ZnSnO_(3)/Cu_(3)P p-n heterojunction for enhanced cancer sonodynamic therapy  

作　　者：Qinyu Zhao Yunchao Zhao Songjing Zhong Zhaoyang Yue Zhuoheng Jiang Shaobo Wang Quanhong Hu Shuncheng Yao Kaikai Wen Linlin Li 

机构地区：[1]School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China [2]Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 101400,China [3]School of Nanoscience and Engineering,University of Chinese Academy of Sciences,Beijing 100049,China [4]College of Chemistry and Material Science,Shandong Agricultural University,Tai’an 271018,China

出　　处：《Chinese Chemical Letters》2024年第12期206-213,共8页中国化学快报（英文版）

基　　金：supported by the National Nature Science Foundation(No.82072065);the Fundamental Research Funds for the Central Universities(No.E2EG6802X2);the National Youth Talent Support Program。

摘　　要：Sonodynamic therapy(SDT)exhibits noninvasive and accuracy in cancer treatment,and has aroused widespread attention.However,the low quantum yield of inorganic sonosensitizers under ultrasound(US)stimulation leads to unsatisfactory efficacy.In this work,an urchin-like piezoelectric ZnSnO_(3)/Cu_(3)P p-n heterojunction was constructed as an efficient sonosensitizer for enhanced SDT.The p-n heterojunction formation narrows the band bandgap and increases the piezoelectric property,which contribute to the promotion of carrier separation and suppression of carrier recombination,resulting in enhanced SDT.Moreover,under tumor microenvironment(TME)with over produced H_(2)O_(2)and glutathione(GSH),Cu_(3)P NNs induce chemodynamic therapy(CDT)by initiating a Fenton-like reaction and depleting GSH,leading to increased cellular oxidative damage.With the combination effect,the Zn Sn O_(3)/Cu_(3)P heterojunction demonstrates a 70%tumor growth inhibition rate in 4T1 tumor mice model.This piezoelectric heterojunction achieves the combined treatment of SDT and CDT,and opens new possibilities for the application of SDT in tumor therapy.

关 键 词：ZnSnO_(3) Piezoelectric effect HETEROJUNCTION Chemodynamic therapy Sonodynamic therapy Reactive oxygen species 

分 类 号：R730.5[医药卫生—肿瘤]