不同SOX基因家族的转录因子表达状态下乳腺癌微钙化的超声影像学评估研究  

Research on the ultrasound imaging evaluation of breast cancer microcalcifications under the expression status of different SOX gene family transcription factors

作　　者：董睿 吕英淑 于雷 于晶晶 DONG Rui;LÜYingshu;YU Lei;YU Jingjing(Department of Glandular surgery,Xingtai Central Hospital,Xingtai 054000,Hebei Province,China)

机构地区：[1]邢台市中心医院腺体外科,河北邢台054000

出　　处：《肿瘤影像学》2024年第6期602-608,共7页Oncoradiology

基　　金：邢台市重点研发计划项目(2023ZZ057)。

摘　　要：目的:探索不同SOX基因家族转录因子表达状态对乳腺癌微钙化超声特征的影响。方法:选取2020年1月—2023年10月邢台市中心医院收治的经病理学检查证实的乳腺癌患者。所有患者均接受手术治疗,从患者病灶处获得乳腺癌组织及距离癌组织≥5 cm的癌旁正常组织,并将所取组织立即保存于-196℃的液氮中待后续研究使用。术前行超声检查,包括常规超声、剪切波弹性成像和超声造影等,术后行病理组织学检测SOX4表达,分析超声学微钙化与SOX4蛋白表达的关系。结果:215例患者乳腺癌组织SOX4高表达比例为86.05%,明显高于癌旁组织的48.84%(χ^(2)=67.783,P=0.000)。乳腺癌微钙化与分化程度、淋巴结转移等临床病理学特征关系密切相关(P<0.05)。乳腺癌SOX4高表达与微钙化、Alder血流分级、周围放射状增强和硬环征等密切关联(P<0.05)。Logistic回归分析显示,微钙化(OR=1.839,95%CI 1.538~2.198)、周围放射状增强(OR=1.795,95%CI 1.089~2.959)和硬环征(OR=1.496,95%CI 1.007~2.223)是乳腺癌SOX4高表达的危险因素(P<0.05)。结论:SOX4在乳腺癌发生和发展中扮演着重要角色,超声影像中微钙化指征与肿瘤分化程度和淋巴结转移密切相关,且微钙化是SOX4高表达的危险因素,临床可应用微钙化指标预测SOX4转录因子表达情况,有望为乳腺癌的早期诊断和治疗方案的制订提供帮助。Objective:To explore the ultrasound imaging evaluation of breast cancer microcalcifications under the expression status of different SOX gene family transcription factors.Methods:The study selected breast cancer patients diagnosed through pathological examination in Xingtai Central Hospital from January 2020 to October 2023.All patients underwent surgical treatment.Breast cancer tissue was obtained from the tumor site,along with adjacent normal tissue at least 5 cm away from the cancerous tissue.The collected tissues were immediately preserved in liquid nitrogen at-196℃for subsequent research.Preoperative ultrasound examinations,including routine ultrasound,shear wave elastography,and contrast-enhanced ultrasound were performed.Postoperative pathological histological testing was conducted to detect SOX4 expression,and the relationship between ultrasonographic microcalcifications and SOX4 protein expression was analyzed.Results:In 215 patients,the proportion of high SOX4 expression in breast cancer tissue was 86.05%,significantly higher than that in adjacent normal tissue,which was 48.84%(χ^(2)=67.783,P=0.000).Breast cancer microcalcifications were closely associated with clinical pathological features such as tumor differentiation and lymph node metastasis(P<0.05).High SOX4 expression in breast cancer was closely correlated with microcalcifications,Alder blood flow grading,peripheral radial enhancement,and the rim sign(P<0.05).Logistic regression analysis showed that microcalcifications(OR=1.839,95%CI 1.538–2.198),peripheral radial enhancement(OR=1.795,95%CI 1.089–2.959),and rim sign(OR=1.496,95%CI 1.007–2.223)were risk factors for high SOX4 expression in breast cancer(P<0.05).Conclusion:SOX4 is implicated as a pivotal contributor to the pathogenesis and progression of breast cancer.The manifestation of microcalcifications in ultrasound imaging exhibits a significant correlation with tumor differentiation and lymph node metastasis, underscoring microcalcification as a prognostic marker for elevated SOX4

关 键 词：乳腺癌 微钙化 超声 SOX基因家族 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]