HPA轴失调与青少年抑郁症非自杀性自伤的研究进展  

The research progress of HPA axis dysregulation and non-suicidal self-injury in adolescents with depressive disorder

作　　者：白羽洁 郭茜[1] 胡昊 刘晓华 Bai Yujie;Guo Qian;Hu Hao;Liu Xiaohua(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,200030

出　　处：《神经疾病与精神卫生》2024年第12期858-862,共5页Journal of Neuroscience and Mental Health

基　　金：上海市公共卫生体系建设三年行动计划(GWV-10.2-XD28);上海申康医院发展中心临研培育项目(SHDC12019X09)。

摘　　要：非自杀性自伤行为在青少年抑郁症患者中较常见,也被认为是自杀行为的最强预测因素。新近研究表明,下丘脑-垂体-肾上腺(HPA)轴失调在该行为中发挥重要作用。本文综述HPA轴与青少年抑郁症非自杀性自伤的研究现状,并从免疫炎症、相关脑区及神经环路等方面阐述了可能的神经生物学机制,以期为青少年抑郁症非自杀性自伤提供新的诊疗思路。Non-suicidal self-injury(NSSI)is common among adolescent depression patients and is also considered the strongest predictor of suicidal behavior.Recent research suggests that hypothalamic-pituitary-adrenal(HPA)axis dysregulation may play an essential role in NSSI.This article reviews the research progress of the relationship between HPA axis and NSSI in adolescents with depression and describes potential mechanisms of inflammation,brain functions and neural circuits,hoping to provide a new diagnosis and treatment idea for NSSI of adolescent depression.

关 键 词：青少年 抑郁症 非自杀性自伤 HPA轴 皮质醇 综述 

分 类 号：R749.4[医药卫生—神经病学与精神病学]