星形胶质细胞在蛛网膜下腔出血中的作用研究进展  

The Role of Astrocytes in Subarachnoid Hemorrhage

作　　者：岁晨 孙新刚[2] SUI Chen;SUN Xingang(The Second Clinical Medical College of Shanxi Medical University,Taiyuan,030000,China;Department of Neurology,the Second Hospital of Shanxi Medical University,Taiyuan,030000,China)

机构地区：[1]山西医科大学第二临床医学院,太原市030000 [2]山西医科大学第二医院神经内科,太原市030000

出　　处：《医学分子生物学杂志》2025年第1期91-96,共6页Journal of Medical Molecular Biology

基　　金：山西省基础研究计划自然科学研究面上项目(No.20210302123264)。

摘　　要：蛛网膜下腔出血(subarachnoid hemorrhage,SAH)是具有高致残率和高死亡率的一种脑血管疾病。星形胶质细胞在SAH后的脑损伤和恢复中起着至关重要的作用。文章对SAH基本概念、SAH后星形胶质细胞的活化和极化、星形胶质细胞参与和介导SAH后的早期脑损伤及迟发性脑缺血等环节以及星形胶质细胞在SAH后与其他脑细胞(如神经元、小胶质细胞和血管内皮细胞)进行大量串扰的情况进行了综述。此外,文章还总结了SAH后关于调节星形胶质细胞功能的相关靶点及治疗方法,为减轻SAH的严重后果及未来的转化疗法提供了一些新的策略。Subarachnoid hemorrhage(SAH)is a cerebrovascular disease that is characterized by a high rate of disability and mortality.Astrocytes play a crucial role in brain injury and recovery following SAH.This paper summarizes the activation and polarization of astrocytes after SAH,their participation and mediation in early brain injury and delayed cerebral ischemia after SAH,and the extensive crosstalk between astrocytes and other brain cells,such as neurons,microglia,and vascular endothelial cells after SAH.In addition,the relevant targets and therapeutic methods for regulating astrocyte function after SAH are also listed here,offering some novel strategies for future translational therapies to alleviate the severe consequences of SAH.

关 键 词：蛛网膜下腔出血 星形胶质细胞 早期脑损伤 迟发性脑缺血 

分 类 号：R743.35[医药卫生—神经病学与精神病学]