归因于酒精暴露所致的中国恶性肿瘤死亡和DALY负担  

Attributing malignant tumor deaths to alcohol exposure and DALY burden in China

作　　者：郑高健 姚潇妮 吴忠泽 贡新宇 陈王洋 庞军委 ZHENG Gaojian;YAO Xiaoni;WU Zhongze;GONG Xinyu;CHEN Wangyang;PANG Junwei(Department of Psychiatry,Taizhou Second People′s Hospital,Taizhou 317200,China;School of Medicine,Taizhou University)

机构地区：[1]台州市第二人民医院精神科,台州317200 [2]台州学院医学院

出　　处：《实用肿瘤学杂志》2024年第5期295-299,共5页Practical Oncology Journal

基　　金：台州市科技计划项目(编号:21ywa63)。

摘　　要：目的分析2021年全球疾病负担数据库评估中国归因于酒精暴露所致恶性肿瘤的死亡和伤残调整寿命年(Disability adjusted life year,DALY),为中国酒精暴露与恶性肿瘤的科学防控提供依据。方法检索2021年全球疾病负担数据库,分析中国恶性肿瘤的死亡数、死亡率、DALY和DALY率,并分析归因于酒精暴露所致的不同性别、不同类型肿瘤的死亡和DALY情况。结果2021年中国恶性肿瘤死亡人数为281.78万,占世界总恶性肿瘤死亡人数的28.50%(281.78万vs.988.84万),中国恶性肿瘤DALY为282.09万人年,占世界恶性肿瘤DALY的30.20%(282.09万人年vs.934.07万人年)。男性归因于酒精暴露所致恶性肿瘤死亡率(12.80/10万vs.1.37/10万)及DALY率(354.08/10万vs.34.96/10万)均高于女性。从年龄分布看,酒精暴露导致的恶性肿瘤死亡率随年龄增长而升高,DALY率在70岁组达到峰值,后又下降。酒精暴露所致疾病负担最高的前三位恶性肿瘤分别为食管癌、肝癌和结直肠癌。结论中国酒精暴露所致恶性肿瘤死亡及DALY负担较重,男性酒精暴露所致的恶性肿瘤死亡高于女性,酒精暴露主要影响消化道肿瘤。男性消化道肿瘤的防治应关注酒精暴露。Objective The objective of this study was to analyze the 2021 global burden of disease database assessment of deaths and disability-adjusted life year(DALY)attributed to alcohol exposure induced malignant tumors in China,providing a scientific basis for the prevention and control of alcohol exposure-related malignancies in China.Methods The 2021 global burden of disease database were retrieved,analyzed the number of deaths and mortality,DALYs,and DALY rates for malignant tumors in China,and analyzed the mortality and DALY situations attributed to alcohol exposure for different gender and types of tumors.Results In 2021,the number of cancer-related deaths in China was 2.8178 million,accounting for 28.50%of the global total cancer deaths(2.8178 million vs.9.8884 million).The DALYs of malignant tumors in China were 2.8209 million person-year,accounting for 30.20%of the global DALY of malignant tumors(2.8209 million person-year vs.9.3407 million person-year).The mortality of malignant tumors attributed to alcohol exposure in males(12.80/100,000 vs.1.37/100,000)and DALY rate(354.08/100,000 vs.34.96/100,000)were higher than those in females.From the perspective of age distribution,the mortality of malignant tumors caused by alcohol exposure increased with age,and the DALY rate reached its peak in the 70-year-old age group and then decreased again.The top three tumors with the highest disease burden caused by alcohol exposure were esophageal cancer,liver cancer,and colorectal cancer.Conclusion Alcohol exposure in China leads to a heavier burden of malignant tumor mortality and DALY,with higher in male malignant tumor mortality than that in females.Alcohol exposure mainly causes gastrointestinal tumors.The prevention and treatment of male gastrointestinal tumors should focus on alcohol exposure.

关 键 词：肿瘤 酒精 疾病负担 归因风险 伤残调整寿命年 

分 类 号：R73[医药卫生—肿瘤]