Amadori与Heyns化合物的合成及其生理功能分析  

Synthesis of Amadori and Heyns Compounds and Their Physiological Function Analysis

作　　者：黎浩然 熊世俊 饶雄飞 余振 杨艳华 兰明蓉 吴哲宽 何蔓[1] 陈贝贝[1] 胡斌[1] LI Haoran;XIONG Shijun;RAO Xiongfei;YU Zhen;YANG Yanhua;LAN Mingrong;WU Zhekuan;HE Man;CHEN Beibei;HU Bin(College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072;Hubei Tobacco Science Research Institute,Wuhan 430030)

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072 [2]湖北省烟草科学研究院,湖北武汉430030

出　　处：《分析科学学报》2024年第6期627-633,共7页Journal of Analytical Science

基　　金：湖北省烟草公司科技项目(027Y2021-002,027Y2022-025)。

摘　　要：在美拉德反应初期阶段,氨基酸与还原糖反应形成了初始的中间体席夫碱,并通过1,2-烯甲醇的重排生成了Amadori化合物与Heyns化合物。近年来,多项研究显示Amadori化合物与Heyns化合物对食品营养价值、烟草风味与疾病治疗有关键影响。为进一步比较二者之间的差异,本文对3种氨基酸对应的Amadori和Heyns化合物的抗氧化性、清除自由基能力以及金属离子螯合能力进行了考察和比较。结果表明,由同一氨基酸生成的Amadori和Heyns化合物的抗氧化能力、自由基清除能力没有显著性差异,而Heyns化合物对Zn^(2+)和Cu^(2+)的螯合能力较强。这一结果说明Amadori和Heyns化合物在生理功能上的贡献不完全相同。在实际分析中,需要对Amadori和Heyns化合物加以区分以阐明二者的作用功效。此外,因两者具有的多种生理功能,它们有作为抗衰老药物以及食品中抗氧化剂的使用前景。In the early stage of the Maillard reaction,amino acids react with reducing sugars to form intermediate Schiff bases,which then undergo rearrangement via 1,2-ene methanol to generate Amadori and Heyns compounds.Recent years,numerous studies have shown that Amadori and Heyns compounds play a crucial role in the nutritional value of food,tobacco flavor,and disease treatment.To clarify the differences between them,Amadori and Heyns compounds corresponding to three amino acids were synthesized.Meanwhile,the antioxidant capacity,radical scavenging ability,and metal ion chelating activity of them were investigated and compared.The results revealed that the antioxidant capacity and radical scavenging abilities of the Amadori and Heyns compounds derived from the same amino acid were generally similar,while Heyns compounds showed stronger chelating activity on Zn^(2+)and Cu^(2+).This result indicated that Amadori and Heyns compounds contribute differently to physiological functions.In practical analysis,it is necessary to distinguish between Amadori and Heyns compounds to clarify their functions and efficacy.Due to their multiple physiological functions,they have the potential to be used as anti-ageing drugs as well as antioxidants in food.

关 键 词：AMADORI化合物 Heyns化合物 生理功能 

分 类 号：Q503[生物学—生物化学]