HSP70在早期胚胎发育中作用的研究进展  

Researchprogress on the role of Hsp70 in early embryonic development

作　　者：欧向阳 丁锦丽[1] 杨哲 张琪璇 吴庚香[1] Ou Xiangyang;Ding Jinli;Yang Zhe;Zhang Qixuan;Wu Gengxiang(Reproductive Medicine Center,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院生殖医学中心,武汉430060

出　　处：《中华生殖与避孕杂志》2024年第11期1196-1199,共4页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(82101749)。

摘　　要：热休克蛋白(heat shock proteins,HSPs)是一组高度保守且功能多样的分子伴侣蛋白,对维持细胞稳态和应对多种应激反应起着至关重要的作用。HSP70是HSPs家族的重要成员之一,参与蛋白质的正确折叠、防止聚集,并在早期胚胎发育中对生殖细胞的形成、DNA损伤修复、受精过程以及胚胎植入等方面发挥关键作用。HSP70通过促进受精卵的正常发育和细胞稳态,维护胚胎健康发育并在各种应激条件下保护细胞免受伤害。通过深入研究HSP70的复杂功能和潜在机制,有望揭示其在原因不明性不孕症、反复着床失败以及复发性流产等疾病中的作用。Heat shock proteins(HSPs)are a group of highly conserved and functionally diverse molecular chaperones that play a crucial role in maintaining cellular homeostasis and coping with a variety of stress responses.HSP70 is one of the important members of the HSPs family,which is involved in the correct folding of proteins,preventing aggregation,and plays a key role in the formation of germ cells,DNA damage repair,fertilization process and embryo implantation in early embryonic development.HSP70 maintains the healthy development of embryos and protects cells from injury under various stress conditions by promoting the normal development and cellular homeostasis of fertilized eggs after fertilization.Through in-depth study of the complex functions and potential mechanisms of HSP7o,it is expected to reveal its role in unexplained infertility,recurrent implantation failure,recurrent abortion and other diseases.

关 键 词：热休克蛋白70 受精卵 胚胎植入 早期胚胎发育 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]