YAP、p65与弥漫大B细胞淋巴瘤临床特征的相关性及临床意义  

Correlation and clinical significance of YAP and p65 with clinical features of diffuse large B-cell lymphoma

作　　者：何人可 林子怡 张闻开 陈远林 张东辉 邓晓芳 HE Renke;LIN Ziyi;ZHANG Wenkai;CHEN Yuanlin;ZHANG Donghui;DENG Xiaofang(Guangzhou Institute of Cancer Research,the Affiliated Cancer Hospital,Guangzhou Medical University,Second Department of Medical Oncology,Guangzhou 510095,China)

机构地区：[1]广州医科大学附属肿瘤医院内二科,广东广州510095

出　　处：《广州医药》2024年第12期1389-1396,1406,共9页Guangzhou Medical Journal

基　　金：国家自然科学基金(81800153)。

摘　　要：目的 探讨Yes1相关蛋白(YAP)及p65在弥漫大B细胞淋巴瘤(DLBCL)中与临床特征的相关性及对DLBCL治疗和预后的意义。方法 收集65例DLBCL和10例反应性增生淋巴结患者组织进行免疫组织化学染色,分析两组差异;对多种临床特征与YAP、p65的相关性进行统计学和生存差异性分析。结果 YAP、p65染色评分在两组间比较差异有统计学意义(P<0.05);YAP评分与疗效分组呈正相关,与治疗前乳酸脱氢酶(LDH)、Ann-Arbor分期、国际预后指数(IPI)呈负相关(P<0.05);p65表达与疗效分组呈负相关,与治疗前LDH水平、Ann-Arbor分组、美国东部肿瘤协作组活动状态评分(ECOG)ECOG分组、结外侵犯、IPI评分、巨大包块呈正相关(P<0.05)。IPI及p65评分是DLBCL患者总生存期(OS)的独立危险因素(P<0.05)。共表达分层中YAP-/p65+组患者OS均值最低。结论 对于DLBCL,YAP低表达或p65高表达提示患者瘤荷较大、较差的疗效和预后。Objective To investigate the correlation of YAP and p65 with clinical features in diffuse large B-cell lymphoma(DLBCL)and the significance for treatment and prognosis.Methods Tissues from 65 patients with DLBCL and 10 patients with reactive hyperplasia lymph node were collected for immunohistochemistry staining to analyze the differences between the two groups;statistical analysis and survival difference analysis of the correlation between various clinical features and YAP,p65 were performed.Results YAP and p65 staining scores were significantly different between the two groups(P<0.05).YAP scores were positively correlated with efficacy subgroups,and negatively correlated with LDH levels before treatment,Ann-Arbor staging,and International Prognostic Index(IPI)scores before treatment(P<0.05);p65 expression was negatively correlated with efficacy subgroups,and positively correlated with pretreatment LDH levels,Ann-Arbor subgroup,ECOG subgroup,extra-nodal invasion,IPI scores,and huge mass(P<0.05).IPI and p65 score were independent prognostic risk factors for overall survival(OS)in DLBCL patients(P<0.05).The mean value of OS was the lowest in patients in the YAP-/p65+group in the co-expression stratification.Conclusions Low expression of YAP or high expression of p65 suggests larger tumor load and poorer outcome and prognosis in patients for DLBCL.

关 键 词：DLBCL Hippo通路 YAP NF-ΚB通路 P65 

分 类 号：R733.1[医药卫生—肿瘤]