DCE-MRI多参数定量特征对乳腺癌腋窝淋巴结转移风险的预测研究  

Prediction of risk of axillary lymph node metastasis in breast cancer by DCE-MRI multi-parameter quantitative feature

作　　者：伍清清 庞溢 梁少芬[1] 杨金生[1] 汪剑晖[1] WU Qingqing;PANG Yi;LIANG Shaofen;YANG Jinsheng;WANG Jianhui(Department of Radiology,Foshan Gaoming District People’s Hospital,Foshan 528500,China)

机构地区：[1]佛山市高明区人民医院放射科,广东佛山528500

出　　处：《广州医药》2024年第12期1450-1455,共6页Guangzhou Medical Journal

基　　金：佛山市卫生健康局医学科研课题(20230039)。

摘　　要：目的探讨动态对比增强磁共振成像(DCE-MRI)多参数定量特征对乳腺癌腋窝淋巴结转移(ALNM)风险的预测价值。方法回顾性收集2020年3月—2022年11月在佛山市高明区人民医院经手术病理确诊的155例乳腺癌患者临床资料,根据患者是否发生ALNM分为ALNM组(n=39)和无ALNM组(n=116)。采用单因素分析和多因素Logistic回归分析乳腺癌发生ALNM的影响因素。结果ALNM组和无ALNM组患者的肿块质地、肿块直径、肿块部位、肿块形状、肿块内部强化特征等指标比较差异无统计学意义(t/χ^(2)=2.249、0.977、1.369、0.524、2.158,P>0.05)。两组患者肿块表观扩散系数(ADC)值、腋窝淋巴结(ALN)短径、肿块边缘、动态增强时间-信号强度曲线(TIC)曲线等指标比较,差异有统计学意义(t/χ^(2)=6.573、9.873、29.441、2.031,P<0.05)。二元Logistic回归模型结果显示,肿块ADC值、ALN短径(≥5 mm)、TIC曲线(流出型)为乳腺癌ALNM发生的危险因素(OR=0.251、0.106、0.002,P<0.05)。结论DCE-MR多参数定量特征中,乳腺癌患者的肿块ADC值低、ALN短径(≥5 mm)、TIC曲线(流出型)为乳腺癌ALNM发生的危险因素。Objective To investigate the predictive value of multi-parameter quantitative features of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)in the risk of axillary lymph node metastasis(ALNM)in breast cancer.Methods Clinical data of 155 patients with breast cancer diagnosed by surgery and pathology in Foshan Gaoming District People’s hospital from March 2020 to November 2022 were retrospectively collected.According to whether the patients had ALNM,they were divided into ALNM group(n=39)and non-ALNM group(n=116).Univariate analysis and multiple Logistic regression models were used to explore the influencing factors of ALNM in breast cancer.Results There was no significant difference in mass texture,mass diameter,mass location,mass shape and internal enhancement between the ALNM group and the non-ALNM group(t/χ^(2)=2.249,0.977,1.369,0.524,2.158,P>0.05).There were significant differences in ADC value,ALN short diameter,tumor margin and TIC curve between the two groups(t/χ^(2)=6.573,9.873,29.441,2.031,P<0.05).Binary Logistic regression model showed that ADC value,ALN short diameter(≥5 mm)and tumor margin(blur)were risk factors for the occurrence of breast cancer ALNM(OR=0.251,0.106,0.002,P<0.05).Conclusions Among the multi-parameter quantitative features of DCE-MRI,the ADC value of breast cancer,the short diameter of ALN(≥5 mm),and the edge of the tumor(blur)are the risk factors for the occurrence of ALNM in breast cancer.

关 键 词：乳腺癌 腋窝淋巴结转移 磁共振 危险因素 预测模型 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]