多潘立酮联合莫沙必利治疗功能性消化不良效果及对症状改善的影响  

The Effect of Panrenone Combined with Mosapride in the Treatment of Functional Dyspepsia and Its Impact on Symptom Improvement

作　　者：李林春 LI Linchun(Department of Internal Medicine,Qingliu County Dengjia Health Center,Sanming,Fujian 365313,China)

机构地区：[1]清流县邓家卫生院内科,福建三明365313

出　　处：《中国医药指南》2025年第1期101-103,共3页Guide of China Medicine

摘　　要：目的探讨多潘立酮联合莫沙必利治疗功能性消化不良(FD)效果及对症状改善的影响。方法选择2022年1月至2024年1月清流县邓家卫生院收治的FD患者200例,采用随机数字表法分为两组,各100例。对照组采用莫沙必利,观察组联用多潘立酮。比较两组临床疗效、症状改善时间、血清指标、不良反应。结果观察组总有效率高于对照组(P<0.05)。观察组嗳气、餐后饱胀、上腹痛、早饱症状改善时间均短于对照组(均P<0.05)。治疗后,观察组血浆促肾上腺皮质激素释放激素(CRH)低于对照组,餐前血浆瘦素、餐后血浆瘦素、胃泌素-17(G-17)、血清胃蛋白酶原Ⅰ(PGⅠ)、血清胃蛋白酶原Ⅱ(PGⅡ)高于对照组(P<0.05)。两组不良反应发生率比较(P>0.05)。结论在FD患者中应用多潘立酮联合莫沙必利治疗的效果显著,可有效缩短症状改善时间,调节血清指标,且用药安全。Objectives To investigate the efficacy of domperidone combined with mosapride in the treatment of functional dyspepsia(FD)and its impact on symptom improvement.Methods A total of 200 FD patients admitted to Dengjia Health Center in Qingliu County from January 2022 to January 2024 were selected and randomly divided into two groups of 100 each using a random number table method.The control group was treated with mosapride,while the observation group was treated with domperidone in combination.Compare the clinical efficacy,symptom improvement time,serum indicators,and adverse reactions between two groups.Results The total effective rate of observation group was higher than that of control group(P<0.05).The improvement time of belching,postmeal fullness,epigastric pain and early satiety in observation group was shorter than that in control group(all P<0.05).After treatment,plasma corticotrophin releasing hormone(CRH)in observation group was lower than that in control group,while plasma leptin before meal,plasma leptin after meal,gastrin-17(G-17),serum pepsinogenⅠ(PG-Ⅰ)and PG-Ⅱwere higher than those in control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The application of domperidone combined with mosapride in the treatment of FD patients has significant effects,can effectively shorten the time for symptom improvement,regulate serum indicators,and is safe to use.

关 键 词：功能性消化不良 多潘立酮 莫沙必利 临床疗效 症状改善 血清指标 

分 类 号：R57[医药卫生—消化系统]