足底静脉泵联合低分子肝素对脑卒中患者下肢深静脉血栓的预防效果  

Prevention effect of plantar venous pump combined with low molecular weight heparin on lower extremity venous thrombosis in stroke patients

作　　者：肖玲 阳丹丹 陈素芬[1] XIAO Ling;YANG Dandan;CHEN Sufen(Changsha Central Hospital Affiliated to University of South China,Changsha 410004,China)

机构地区：[1]南华大学附属长沙中心医院,长沙市410004

出　　处：《临床合理用药》2024年第36期29-32,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：南华大学临床医学研究“4310”计划项目(20214310NHYPY10)。

摘　　要：目的观察足底静脉泵联合低分子肝素对脑卒中患者下肢深静脉血栓的预防效果。方法按照随机数字表法将2020年1—12月南华大学附属长沙中心医院收治的脑卒中患者80例分为观察组(40例,给予足底静脉泵联合低分子肝素钙注射液治疗)和常规组(40例,给予低分子肝素钙注射液治疗)。2组均治疗2周。比较2组治疗前后血液流变学指标、双下肢血管指标与大腿、小腿周径及Fugl-Meyer评定量表(FMA)评分,下肢深静脉血栓发生率。结果治疗2周后,2组全血高切黏度、全血低切黏度、血浆黏度低于治疗前,且观察组低于常规组(P<0.05或P<0.01);2组双下肢静脉血管内径、血流量大于治疗前,平均血流速度低于治疗前,大腿、小腿周径小于治疗前,且观察组改善幅度大于常规组(P<0.01);2组FAM评分高于治疗前,且观察组高于常规组(P<0.01)。观察组下肢深静脉血栓发生率低于常规组(0 vs.15.00%,χ^(2)=4.505,P=0.034)。结论足底静脉泵联合低分子肝素对脑卒中患者下肢深静脉血栓的预防效果良好,可有效改善患者血液流变学与下肢循环,增加下肢血流量,降低下肢深静脉血栓发生率。Objective To observe the preventive effect of plantar venous pump combined with low molecular weight heparin on lower extremity venous thrombosis in stroke patients.Methods According to the random number table method,80 cases of stroke patients admitted to Changsha Central Hospital Affiliated to University of South China from January to December 2020 were divided into the observation group with 40 cases(who were treated with plantar venous pump combined with low molecular weight heparin calcium injection)and the conventional group with 40 cases(who were treated with low molecular weight heparin calcium injection),both groups were treated for 2 weeks.Hemorheological indicators,vascular index of both lower limbs,circumferential diameter of thigh and calf,FMA score before and after treatment,and incidence of lower extremity venous thrombosis were compared between the two groups.Results After 2 weeks of treatment,the whole blood high-shear viscosity,whole blood low-shear viscosity,and plasma viscosity in the two groups were lower than those before treatment,and those in the observation group were lower than the conventional group(P<0.05 or P<0.01);Diameter and blood flow of venous vessels in both lower limbs in the two groups were greater than those before treatment,the average blood flow velocity was lower than that before treatment,and the circumference of thigh and calf were smaller than those before treatment,and the observation group were better than those in the conventional group(P<0.01);FMA score in the two groups was higher than that before treatment,and the observation group was higher than that in the conventional group(P<0.01).Incidence of lower extremity venous thrombosis in the observation group was lower than that in the conventional group(0 vs.15.00%,χ^(2)=4.505,P=0.034).Conclusion The use of plantar venous pump combined with low molecular weight heparin have good preventive effect on lower extremity venous thrombosis in stroke patients,it can effectively improve hemorheology and lower extremity circ

关 键 词：脑卒中 下肢深静脉血栓 足底静脉泵 低分子肝素 预防效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]