饮食摄入与注意缺陷多动障碍的因果关联:两样本孟德尔随机化  

Causal association between dietary intake and attention deficit hyperactivity disorder:a two-sample Mendelian randomization

作　　者：张蔷 周康宁 袁振华 刘苗苗 刘拓 王俊宏[1] ZHANG Qiang;ZHOU Kang-ning;YUAN Zhen-hua;LIU Miao-miao;LIU Tuo;WANG Jun-hong(Department of Pediatrics,Dongzhimen Hospital,Bejjing University of Chinese Medicine,Beijing 101700,China;不详)

机构地区：[1]北京中医药大学东直门医院儿科,北京101700 [2]中国中医科学院中药研究所

出　　处：《现代预防医学》2024年第24期4465-4472,4504,共9页Modern Preventive Medicine

基　　金：国家自然科学基金面上项目(82274581);首都卫生发展科研专项项目(首发2020-2Z-4196);北京中医药大学基本科研业务费揭榜挂帅项目(2023-JYB-JBZD-011)。

摘　　要：目的饮食摄入与注意缺陷多动障碍(ADHD)的确切因果关联尚不明确,本研究采用两样本、双向孟德尔随机化(MR)进行二者的因果关联分析。方法从全基因组关联研究(GWAS)的汇总数据中提取与饮食摄入相关的单核苷酸多态性(SNP)位点作为工具变量(IV)。使用R软件中的TwoSampleMR包对饮食摄入与ADHD之间的因果关联进行分析。所采用的主要方法包括逆方差加权法(IVW)、MR Egger和加权中位数法。采用Cochran Q、MR-Egger和“留一法”分别进行异质性检验、多效性检验、敏感性分析。结果IVW结果显示牛油果(OR=0.309,95%CI:0.132~0.719)、芹菜(OR=0.503,95%CI:0.380~0.905)、羊肉/羔羊肉(OR=0.349,95%CI:0.170~0.715)、贝类(OR=0.083,95%CI:0.011~0.638)、葡萄柚(OR=0.175,95%CI:0.043~0.711)和油性鱼(OR=0.687,95%CI:0.492~0.960)与ADHD的发生呈负相关,馕饼(OR=4.109,95%CI:1.079~15.648)、每周平均烈性酒摄入(OR=3.320,95%CI:1.419~7.767)、麦片中人工甜味添加剂(OR=5.064,95%CI:1.507~17.017)和标准茶(OR=1.004,95%CI:1.002~1.007)与ADHD的发生呈正相关。结论增加牛油果、芹菜、羊肉/羔羊肉、贝类、葡萄柚和油性鱼的摄入降低了ADHD的发生风险,而增加馕饼、每周烈性酒摄入、人工甜味添加剂和标准茶的摄入提高了ADHD的发生风险。Objective The exact causal association between dietary intake and attention deficit hyperactivity disorder(ADHD)is unclear,and this study used two-sample,two-way Mendelian randomization(MR)to conduct causal association analyses between them.Methods Single nucleotide polymorphism(SNP)loci associated with dietaryintake were extracted from the pooled data of genome-wide association studies(GWAS)as instrumental variables(IV).Causal associations between dietary intake and ADHD were analyzed using the TwoSampleMR package in R software.The main methods used included inverse variance weighting(IVW),MR Egger and weighted median tests.Cochran’Q,MR-Egger,and the"leave-one-out"method were used for heterogeneity test,pleiotropy test,and sensitivity analysis,respectively.Results The IVW results showed that avocado(OR=0.309,95%CI:0.132-0.719),celery(OR=0.503,95%CI:0.380-0.905),mutton/lamb(OR=0.349,95%CI:0.170-0.715),shellfish(OR=0.083,95%CI:0.011-0.638),grapefruit(OR=0.175,95%CI:0.043-0.711)and oily fish(OR=0.687,95%CI:0.492-0.960)were negatively associated with the development of ADHD,and naan bread(OR=4.109,95%CI:1.079-15.648),average weekly intake of spirits(OR=3.320,95%CI:1.419-7.767),intake of artificial sweetener added to cereal(OR=5.064,95%CI:1.507-17.017),and standard Tea(OR=1.004,95%CI:1.002-1.007)were positively associated with the development of ADHD.Conclusion Increased intake of avocado,celery,mutton/lamb,shellfish,grapefruit,and oily fish reduced the risk of ADHD,whereas increased intake of naan bread,average weekly spirits intake,Intake of artificial sweetener added to cereal,and standard tea raised the risk of ADHD.

关 键 词：饮食摄入 注意缺陷多动障碍 因果关联 孟德尔随机化 

分 类 号：R749.94[医药卫生—神经病学与精神病学]