铁死亡与肿瘤免疫  

Ferroptosis and tumor immunity

作　　者：陶倩 刘念 陈静[1,2,3,4,5,6] 伍劼 李捷 陈翔[1,2,3,4,5,6] 彭聪 TAO Qian;LIU Nian;CHEN Jing;WU Jie;LI Jie;CHEN Xiang;PENG Cong(Department of Dermatology,Xiangya Hospital,Central South University,Changsha 410008;Hunan Key Laboratory of Skin Cancer and Psoriasis,Changsha 410008;Hunan Engineering Research Center of Skin Health and Disease,Changsha 410008;Furong Laboratory,Changsha 410078;National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology,Changsha 410008;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院皮肤科,长沙410008 [2]皮肤肿瘤与银屑病湖南省重点实验室,长沙410008 [3]皮肤健康与疾病湖南省工程研究中心,长沙410008 [4]芙蓉实验室,长沙410078 [5]个体化诊疗技术国家工程技术研究中心,长沙410008 [6]国家老年疾病临床医学研究中心(湘雅医院),长沙410008

出　　处：《中南大学学报（医学版）》2024年第8期1309-1315,共7页Journal of Central South University ：Medical Science

基　　金：国家自然科学基金(82203024)。

摘　　要：铁死亡是一种依赖铁的脂质过氧化驱动的独特细胞死亡形式,其调节机制涉及代谢紊乱和氧化还原系统的失衡。铁死亡与肿瘤免疫微环境中的多种免疫细胞(包括抗肿瘤和促肿瘤免疫细胞)密切相关,并在肿瘤免疫治疗中展现出巨大潜力。系统回顾铁死亡的调节机制及其与免疫细胞的关系,有助于深入了解其在肿瘤免疫治疗中的应用前景。Ferroptosis is a unique form of cell death driven by iron-dependent lipid peroxidation,with regulatory mechanisms involving metabolic dysregulation and imbalance in redox systems.Ferroptosis is closely related to various immune cells in the tumor immune microenvironment,including both anti-tumor and pro-tumor immune cells,and it demonstrates significant potential in tumor immunotherapy.A systematic review of the regulatory mechanisms of ferroptosis and its relationship with immune cells can provide deeper insights into its application prospects in tumor immunotherapy.

关 键 词：铁死亡 免疫细胞 肿瘤免疫治疗 

分 类 号：R730.3[医药卫生—肿瘤]